Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
1_MELAA 6_ LCRWG 11_ LLLAL 16_ LPPGA 21_ ASTQV 26_ CTGTD 31_ MKLRL 36_ PASPE 41_ THLDM 46_ LRHLY 51_ QGCQV 56_ VQGNL 61_ ELTYL 66_ PTNAS 71_ LSFLQ 76_ DIQEV 81_ QGYVL 86_ IAHNQ 91_ VRQVP 96_ LQRLR 101_ IVRGT 106_ QLFED 111_ NYALA 116_ VLDNG 121_ DPLNN 126_ TTPVT 131_ GASPG 136_ GLREL 141_ QLRSL 146_ TEILK 151_ GGVLI 156_ QRNPQ 161_ LCYQD 166_ TILWK 171_ DIFHK 176_ NNQLA 181_ LTLID 186_ TNRSR 191_ ACHPC 196_ SPMCK 201_ GSRCW 206_ GESSE 211_ DCQSL 216_ TRTVC 221_ AGGCA 226_ RCKGP 231_ LPTDC 236_ CHEQC 241_ AAGCT 246_ GPKHS 251_ DCLAC 256_ LHFNH 261_ SGICE 266_ LHCPA 271_ LVTYN 276_ TDTFE 281_ SMPNP 286_ EGRYT 291_ FGASC 296_ VTACP 301_ YNYLS 306_ TDVGS 311_ CTLVC 316_ PLHNQ 321_ EVTAE 326_ DGTQR 331_ CEKCS 336_ KPCAR 341_ VCYGL 346_ GMEHL 351_ REVRA 356_ VTSAN 361_ IQEFA 366_ GCKKI 371_ FGSLA 376_ FLPES 381_ FDGDP 386_ ASNTA 391_ PLQPE 396_ QLQVF 401_ ETLEE 406_ ITGYL 411_ YISAW 416_ PDSLP 421_ DLSVF 426_ QNLQV 431_ IRGRI 436_ LHNGA 441_ YSLTL 446_ QGLGI 451_ SWLGL 456_ RSLRE 461_ LGSGL 466_ ALIHH 471_ NTHLC 476_ FVHTV 481_ PWDQL 486_ FRNPH 491_ QALLH 496_ TANRP 501_ EDECV 506_ GEGLA 511_ CHQLC 516_ ARGHC 521_ WGPGP 526_ TQCVN 531_ CSQFL 536_ RGQEC 541_ VEECR 546_ VLQGL 551_ PREYV 556_ NARHC 561_ LPCHP 566_ ECQPQ 571_ NGSVT 576_ CFGPE 581_ ADQCV 586_ ACAHY 591_ KDPPF 596_ CVARC 601_ PSGVK 606_ PDLSY 611_ MPIWK 616_ FPDEE 621_ GACQP 626_ CPINC 631_ THSCV 636_ DLDDK 641_ GCPAE 646_ QRASP 651_ LTSII 656_ SAVVG 661_ ILLVV 666_ VLGVV 671_ FGILI 676_ KRRQQ 681_ KIRKY 686_ TMRRL 691_ LQETE 696_ LVEPL 701_ TPSGA 706_ MPNQA 711_ QMRIL 716_ KETEL 721_ RKVKV 726_ LGSGA 731_ FGTVY 736_ KGIWI 741_ PDGEN 746_ VKIPV 751_ AIKVL 756_ RENTS 761_ PKANK 766_ EILDE 771_ AYVMA 776_ GVGSP 781_ YVSRL 786_ LGICL 791_ TSTVQ 796_ LVTQL 801_ MPYGC 806_ LLDHV 811_ RENRG 816_ RLGSQ 821_ DLLNW 826_ CMQIA 831_ KGMSY 836_ LEDVR 841_ LVHRD 846_ LAARN 851_ VLVKS 856_ PNHVK 861_ ITDFG 866_ LARLL 871_ DIDET 876_ EYHAD 881_ GGKVP 886_ IKWMA 891_ LESIL 896_ RRRFT 901_ HQSDV 906_ WSYGV 911_ TVWEL 916_ MTFGA 921_ KPYDG 926_ IPARE 931_ IPDLL 936_ EKGER 941_ LPQPP 946_ ICTID 951_ VYMIM 956_ VKCWM 961_ IDSEC 966_ RPRFR 971_ ELVSE 976_ FSRMA 981_ RDPQR 986_ FVVIQ 991_ NEDLG 996_ PASPL 1001_ DSTFY 1006_ RSLLE 1011_ DDDMG 1016_ DLVDA 1021_ EEYLV 1026_ PQQGF 1031_ FCPDP 1036_ APGAG 1041_ GMVHH 1046_ RHRSS 1051_ STRSG 1056_ GGDLT 1061_ LGLEP 1066_ SEEEA 1071_ PRSPL 1076_ APSEG 1081_ AGSDV 1086_ FDGDL 1091_ GMGAA 1096_ KGLQS 1101_ LPTHD 1106_ PSPLQ 1111_ RYSED 1116_ PTVPL 1121_ PSETD 1126_ GYVAP 1131_ LTCSP 1136_ QPEYV 1141_ NQPDV 1146_ RPQPP 1151_ SPREG 1156_ PLPAA 1161_ RPAGA 1166_ TLERP 1171_ KTLSP 1176_ GKNGV 1181_ VKDVF 1186_ AFGGA 1191_ VENPE 1196_ YLTPQ 1201_ GGAAP 1206_ QPHPP 1211_ PAFSP 1216_ AFDNL 1221_ YYWDQ 1226_ DPPER 1231_ GAPPS 1236_ TFKGT 1241_ PTAEN 1246_PEYLG
1: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
2: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth