Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog)
1_MGLWA 6_ LLPGW 11_ VSATL 16_ LLALA 21_ ALPAA 26_ LAANS 31_ SGRWW 36_ GIVNV 41_ ASSTN 46_ LLTDS 51_ KSLQL 56_ VLEPS 61_ LQLLS 66_ RKQRR 71_ LIRQN 76_ PGILH 81_ SVSGG 86_ LQSAV 91_ RECKW 96_ QFRNR 101_ RWNCP 106_ TAPGP 111_ HLFGK 116_ IVNRG 121_ CRETA 126_ FIFAI 131_ TSAGV 136_ THSVA 141_ RSCSE 146_ GSIES 151_ CTCDY 156_ RRRGP 161_ GGPDW 166_ HWGGC 171_ SDNID 176_ FGRLF 181_ GREFV 186_ DSGEK 191_ GRDLR 196_ FLMNL 201_ HNNEA 206_ GRTTV 211_ FSEMR 216_ QECKC 221_ HGMSG 226_ SCTVR 231_ TCWMR 236_ LPTLR 241_ AVGDV 246_ LRDRF 251_ DGASR 256_ VLYGN 261_ RGSNR 266_ ASRAE 271_ LLRLE 276_ PEDPA 281_ HKPPS 286_ PHDLV 291_ YFEKS 296_ PNFCT 301_ YSGRL 306_ GTAGT 311_ AGRAC 316_ NSSSP 321_ ALDGC 326_ ELLCC 331_ GRGHR 336_ TRTQR 341_ VTERC 346_ NCTFH 351_ WCCHV 356_ SCRNC 361_THTRV
1: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:23656646, PubMed:26902720, PubMed:28528193). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646)