High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
1_MLRGG 6_ RRGQL 11_ GWHSW 16_ AAGPG 21_ SLLAW 26_ LILAS 31_ AGAAP 36_ CPDAC 41_ CPHGS 46_ SGLRC 51_ TRDGA 56_ LDSLH 61_ HLPGA 66_ ENLTE 71_ LYIEN 76_ QQHLQ 81_ HLELR 86_ DLRGL 91_ GELRN 96_ LTIVK 101_ SGLRF 106_ VAPDA 111_ FHFTP 116_ RLSRL 121_ NLSFN 126_ ALESL 131_ SWKTV 136_ QGLSL 141_ QELVL 146_ SGNPL 151_ HCSCA 156_ LRWLQ 161_ RWEEE 166_ GLGGV 171_ PEQKL 176_ QCHGQ 181_ GPLAH 186_ MPNAS 191_ CGVPT 196_ LKVQV 201_ PNASV 206_ DVGDD 211_ VLLRC 216_ QVEGR 221_ GLEQA 226_ GWILT 231_ ELEQS 236_ ATVMK 241_ SGGLP 246_ SLGLT 251_ LANVT 256_ SDLNR 261_ KNVTC 266_ WAEND 271_ VGRAE 276_ VSVQV 281_ NVSFP 286_ ASVQL 291_ HTAVE 296_ MHHWC 301_ IPFSV 306_ DGQPA 311_ PSLRW 316_ LFNGS 321_ VLNET 326_ SFIFT 331_ EFLEP 336_ AANET 341_ VRHGC 346_ LRLNQ 351_ PTHVN 356_ NGNYT 361_ LLAAN 366_ PFGQA 371_ SASIM 376_ AAFMD 381_ NPFEF 386_ NPEDP 391_ IPVSF 396_ SPVDT 401_ NSTSG 406_ DPVEK 411_ KDETP 416_ FGVSV 421_ AVGLA 426_ VFACL 431_ FLSTL 436_ LLVLN 441_ KCGRR 446_ NKFGI 451_ NRPAV 456_ LAPED 461_ GLAMS 466_ LHFMT 471_ LGGSS 476_ LSPTE 481_ GKGSG 486_ LQGHI 491_ IENPQ 496_ YFSDA 501_ CVHHI 506_ KRRDI 511_ VLKWE 516_ LGEGA 521_ FGKVF 526_ LAECH 531_ NLLPE 536_ QDKML 541_ VAVKA 546_ LKEAS 551_ ESARQ 556_ DFQRE 561_ AELLT 566_ MLQHQ 571_ HIVRF 576_ FGVCT 581_ EGRPL 586_ LMVFE 591_ YMRHG 596_ DLNRF 601_ LRSHG 606_ PDAKL 611_ LAGGE 616_ DVAPG 621_ PLGLG 626_ QLLAV 631_ ASQVA 636_ AGMVY 641_ LAGLH 646_ FVHRD 651_ LATRN 656_ CLVGQ 661_ GLVVK 666_ IGDFG 671_ MSRDI 676_ YSTDY 681_ YRVGG 686_ RTMLP 691_ IRWMP 696_ PESIL 701_ YRKFT 706_ TESDV 711_ WSFGV 716_ VLWEI 721_ FTYGK 726_ QPWYQ 731_ LSNTE 736_ AIDCI 741_ TQGRE 746_ LERPR 751_ ACPPE 756_ VYAIM 761_ RGCWQ 766_ REPQQ 771_ RHSIK 776_ DVHAR 781_ LQALA 786_ QAPPV 791_YLDVL
1: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors
2: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed