Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
1_MLFPI 6_ SMSAT 11_ EFLLA 16_ SVIFC 21_ LVFWV 26_ IRASR 31_ PQVPK 36_ GLKNP 41_ PGPWG 46_ WPLIG 51_ HMLTL 56_ GKNPH 61_ LALSR 66_ MSQQY 71_ GDVLQ 76_ IRIGS 81_ TPVVV 86_ LSGLD 91_ TIRQA 96_ LVRQG 101_ DDFKG 106_ RPDLY 111_ TFTLI 116_ SNGQS 121_ MSFSP 126_ DSGPV 131_ WAARR 136_ RLAQN 141_ GLKSF 146_ SIASD 151_ PASST 156_ SCYLE 161_ EHVSK 166_ EAEVL 171_ ISTLQ 176_ ELMAG 181_ PGHFN 186_ PYRYV 191_ VVSVT 196_ NVICA 201_ ICFGR 206_ RYDHN 211_ HQELL 216_ SLVNL 221_ NNNFG 226_ EVVGS 231_ GNPAD 236_ FIPIL 241_ RYLPN 246_ PSLNA 251_ FKDLN 256_ EKFYS 261_ FMQKM 266_ VKEHY 271_ KTFEK 276_ GHIRD 281_ ITDSL 286_ IEHCQ 291_ EKQLD 296_ ENANV 301_ QLSDE 306_ KIINI 311_ VLDLF 316_ GAGFD 321_ TVTTA 326_ ISWSL 331_ MYLVM 336_ NPRVQ 341_ RKIQE 346_ ELDTV 351_ IGRSR 356_ RPRLS 361_ DRSHL 366_ PYMEA 371_ FILET 376_ FRHSS 381_ FVPFT 386_ IPHST 391_ TRDTS 396_ LKGFY 401_ IPKGR 406_ CVFVN 411_ QWQIN 416_ HDQKL 421_ WVNPS 426_ EFLPE 431_ RFLTP 436_ DGAID 441_ KVLSE 446_ KVIIF 451_ GMGKR 456_ KCIGE 461_ TIARW 466_ EVFLF 471_ LAILL 476_ QRVEF 481_ SVPLG 486_ VKVDM 491_ TPIYG 496_ LTMKH 501_ ACCEH 506_FQMQL
1: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195)