Gene name: TYMS

Uniprot entry:

P04818

Protein names:

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

Protein sequence:

1_MPVAG 6_ SELPR 11_ RPLPP 16_ AAQER 21_ DAEPR 26_ PPHGE 31_ LQYLG 36_ QIQHI 41_ LRCGV 46_ RKDDR 51_ TGTGT 56_ LSVFG 61_ MQARY 66_ SLRDE 71_ FPLLT 76_ TKRVF 81_ WKGVL 86_ EELLW 91_ FIKGS 96_ TNAKE 101_ LSSKG 106_ VKIWD 111_ ANGSR 116_ DFLDS 121_ LGFST 126_ REEGD 131_ LGPVY 136_ GFQWR 141_ HFGAE 146_ YRDME 151_ SDYSG 156_ QGVDQ 161_ LQRVI 166_ DTIKT 171_ NPDDR 176_ RIIMC 181_ AWNPR 186_ DLPLM 191_ ALPPC 196_ HALCQ 201_ FYVVN 206_ SELSC 211_ QLYQR 216_ SGDMG 221_ LGVPF 226_ NIASY 231_ ALLTY 236_ MIAHI 241_ TGLKP 246_ GDFIH 251_ TLGDA 256_ HIYLN 261_ HIEPL 266_ KIQLQ 271_ REPRP 276_ FPKLR 281_ ILRKV 286_ EKIDD 291_ FKAED 296_ FQIEG 301_ YNPHP 306_TIKME

Protein annotations

Protein functions:

1: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway