Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)
1_MGNWA 6_ VNEGL 11_ SIFVI 16_ LVWLG 21_ LNVFL 26_ FVWYY 31_ RVYDI 36_ PPKFF 41_ YTRKL 46_ LGSAL 51_ ALARA 56_ PAACL 61_ NFNCM 66_ LILLP 71_ VCRNL 76_ LSFLR 81_ GSSAC 86_ CSTRV 91_ RRQLD 96_ RNLTF 101_ HKMVA 106_ WMIAL 111_ HSAIH 116_ TIAHL 121_ FNVEW 126_ CVNAR 131_ VNNSD 136_ PYSVA 141_ LSELG 146_ DRQNE 151_ SYLNF 156_ ARKRI 161_ KNPEG 166_ GLYLA 171_ VTLLA 176_ GITGV 181_ VITLC 186_ LILII 191_ TSSTK 196_ TIRRS 201_ YFEVF 206_ WYTHH 211_ LFVIF 216_ FIGLA 221_ IHGAE 226_ RIVRG 231_ QTAES 236_ LAVHN 241_ ITVCE 246_ QKISE 251_ WGKIK 256_ ECPIP 261_ QFAGN 266_ PPMTW 271_ KWIVG 276_ PMFLY 281_ LCERL 286_ VRFWR 291_ SQQKV 296_ VITKV 301_ VTHPF 306_ KTIEL 311_ QMKKK 316_ GFKME 321_ VGQYI 326_ FVKCP 331_ KVSKL 336_ EWHPF 341_ TLTSA 346_ PEEDF 351_ FSIHI 356_ RIVGD 361_ WTEGL 366_ FNACG 371_ CDKQE 376_ FQDAW 381_ KLPKI 386_ AVDGP 391_ FGTAS 396_ EDVFS 401_ YEVVM 406_ LVGAG 411_ IGVTP 416_ FASIL 421_ KSVWY 426_ KYCNN 431_ ATNLK 436_ LKKIY 441_ FYWLC 446_ RDTHA 451_ FEWFA 456_ DLLQL 461_ LESQM 466_ QERNN 471_ AGFLS 476_ YNIYL 481_ TGWDE 486_ SQANH 491_ FAVHH 496_ DEEKD 501_ VITGL 506_ KQKTL 511_ YGRPN 516_ WDNEF 521_ KTIAS 526_ QHPNT 531_ RIGVF 536_ LCGPE 541_ ALAET 546_ LSKQS 551_ ISNSE 556_ SGPRG 561_VHFIF
1: Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:15338276, PubMed:36241643, PubMed:36413210, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable) (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:19028840, PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (By similarity)