Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
1_MGCTV 6_ SAEDK 11_ AAAER 16_ SKMID 21_ KNLRE 26_ DGEKA 31_ AREVK 36_ LLLLG 41_ AGESG 46_ KSTIV 51_ KQMKI 56_ IHEDG 61_ YSEEE 66_ CRQYR 71_ AVVYS 76_ NTIQS 81_ IMAIV 86_ KAMGN 91_ LQIDF 96_ ADPSR 101_ ADDAR 106_ QLFAL 111_ SCTAE 116_ EQGVL 121_ PDDLS 126_ GVIRR 131_ LWADH 136_ GVQAC 141_ FGRSR 146_ EYQLN 151_ DSAAY 156_ YLNDL 161_ ERIAQ 166_ SDYIP 171_ TQQDV 176_ LRTRV 181_ KTTGI 186_ VETHF 191_ TFKDL 196_ HFKMF 201_ DVGGQ 206_ RSERK 211_ KWIHC 216_ FEGVT 221_ AIIFC 226_ VALSA 231_ YDLVL 236_ AEDEE 241_ MNRMH 246_ ESMKL 251_ FDSIC 256_ NNKWF 261_ TDTSI 266_ ILFLN 271_ KKDLF 276_ EEKIT 281_ HSPLT 286_ ICFPE 291_ YTGAN 296_ KYDEA 301_ ASYIQ 306_ SKFED 311_ LNKRK 316_ DTKEI 321_ YTHFT 326_ CATDT 331_ KNVQF 336_ VFDAV 341_ TDVII 346_KNNLK
1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool