Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)
1_MGKGV 6_ GRDKY 11_ EPAAV 16_ SEQGD 21_ KKGKK 26_ GKKDR 31_ DMDEL 36_ KKEVS 41_ MDDHK 46_ LSLDE 51_ LHRKY 56_ GTDLS 61_ RGLTS 66_ ARAAE 71_ ILARD 76_ GPNAL 81_ TPPPT 86_ TPEWI 91_ KFCRQ 96_ LFGGF 101_ SMLLW 106_ IGAIL 111_ CFLAY 116_ SIQAA 121_ TEEEP 126_ QNDNL 131_ YLGVV 136_ LSAVV 141_ IITGC 146_ FSYYQ 151_ EAKSS 156_ KIMES 161_ FKNMV 166_ PQQAL 171_ VIRNG 176_ EKMSI 181_ NAEEV 186_ VVGDL 191_ VEVKG 196_ GDRIP 201_ ADLRI 206_ ISANG 211_ CKVDN 216_ SSLTG 221_ ESEPQ 226_ TRSPD 231_ FTNEN 236_ PLETR 241_ NIAFF 246_ STNCV 251_ EGTAR 256_ GIVVY 261_ TGDRT 266_ VMGRI 271_ ATLAS 276_ GLEGG 281_ QTPIA 286_ AEIEH 291_ FIHII 296_ TGVAV 301_ FLGVS 306_ FFILS 311_ LILEY 316_ TWLEA 321_ VIFLI 326_ GIIVA 331_ NVPEG 336_ LLATV 341_ TVCLT 346_ LTAKR 351_ MARKN 356_ CLVKN 361_ LEAVE 366_ TLGST 371_ STICS 376_ DKTGT 381_ LTQNR 386_ MTVAH 391_ MWFDN 396_ QIHEA 401_ DTTEN 406_ QSGVS 411_ FDKTS 416_ ATWLA 421_ LSRIA 426_ GLCNR 431_ AVFQA 436_ NQENL 441_ PILKR 446_ AVAGD 451_ ASESA 456_ LLKCI 461_ ELCCG 466_ SVKEM 471_ RERYA 476_ KIVEI 481_ PFNST 486_ NKYQL 491_ SIHKN 496_ PNTSE 501_ PQHLL 506_ VMKGA 511_ PERIL 516_ DRCSS 521_ ILLHG 526_ KEQPL 531_ DEELK 536_ DAFQN 541_ AYLEL 546_ GGLGE 551_ RVLGF 556_ CHLFL 561_ PDEQF 566_ PEGFQ 571_ FDTDD 576_ VNFPI 581_ DNLCF 586_ VGLIS 591_ MIDPP 596_ RAAVP 601_ DAVGK 606_ CRSAG 611_ IKVIM 616_ VTGDH 621_ PITAK 626_ AIAKG 631_ VGIIS 636_ EGNET 641_ VEDIA 646_ ARLNI 651_ PVSQV 656_ NPRDA 661_ KACVV 666_ HGSDL 671_ KDMTS 676_ EQLDD 681_ ILKYH 686_ TEIVF 691_ ARTSP 696_ QQKLI 701_ IVEGC 706_ QRQGA 711_ IVAVT 716_ GDGVN 721_ DSPAL 726_ KKADI 731_ GVAMG 736_ IAGSD 741_ VSKQA 746_ ADMIL 751_ LDDNF 756_ ASIVT 761_ GVEEG 766_ RLIFD 771_ NLKKS 776_ IAYTL 781_ TSNIP 786_ EITPF 791_ LIFII 796_ ANIPL 801_ PLGTV 806_ TILCI 811_ DLGTD 816_ MVPAI 821_ SLAYE 826_ QAESD 831_ IMKRQ 836_ PRNPK 841_ TDKLV 846_ NERLI 851_ SMAYG 856_ QIGMI 861_ QALGG 866_ FFTYF 871_ VILAE 876_ NGFLP 881_ IHLLG 886_ LRVDW 891_ DDRWI 896_ NDVED 901_ SYGQQ 906_ WTYEQ 911_ RKIVE 916_ FTCHT 921_ AFFVS 926_ IVVVQ 931_ WADLV 936_ ICKTR 941_ RNSVF 946_ QQGMK 951_ NKILI 956_ FGLFE 961_ ETALA 966_ AFLSY 971_ CPGMG 976_ VALRM 981_ YPLKP 986_ TWWFC 991_ AFPYS 996_ LLIFV 1001_ YDEVR 1006_ KLIIR 1011_ RRPGG 1016_WVEKE
1: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)