Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
1_MARGK 6_ AKEEG 11_ SWKKF 16_ IWNSE 21_ KKEFL 26_ GRTGG 31_ SWFKI 36_ LLFYV 41_ IFYGC 46_ LAGIF 51_ IGTIQ 56_ VMLLT 61_ ISEFK 66_ PTYQD 71_ RVAPP 76_ GLTQI 81_ PQIQK 86_ TEISF 91_ RPNDP 96_ KSYEA 101_ YVLNI 106_ VRFLE 111_ KYKDS 116_ AQRDD 121_ MIFED 126_ CGDVP 131_ SEPKE 136_ RGDFN 141_ HERGE 146_ RKVCR 151_ FKLEW 156_ LGNCS 161_ GLNDE 166_ TYGYK 171_ EGKPC 176_ IIIKL 181_ NRVLG 186_ FKPKP 191_ PKNES 196_ LETYP 201_ VMKYN 206_ PNVLP 211_ VQCTG 216_ KRDED 221_ KDKVG 226_ NVEYF 231_ GLGNS 236_ PGFPL 241_ QYYPY 246_ YGKLL 251_ QPKYL 256_ QPLLA 261_ VQFTN 266_ LTMDT 271_ EIRIE 276_ CKAYG 281_ ENIGY 286_ SEKDR 291_ FQGRF 296_DVKIE
1: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520)
2: Involved in cell adhesion and establishing epithelial cell polarity