Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase)
1_MAHRF 6_ PALTQ 11_ EQKKE 16_ LSEIA 21_ QSIVA 26_ NGKGI 31_ LAADE 36_ SVGTM 41_ GNRLQ 46_ RIKVE 51_ NTEEN 56_ RRQFR 61_ EILFS 66_ VDSSI 71_ NQSIG 76_ GVILF 81_ HETLY 86_ QKDSQ 91_ GKLFR 96_ NILKE 101_ KGIVV 106_ GIKLD 111_ QGGAP 116_ LAGTN 121_ KETTI 126_ QGLDG 131_ LSERC 136_ AQYKK 141_ DGVDF 146_ GKWRA 151_ VLRIA 156_ DQCPS 161_ SLAIQ 166_ ENANA 171_ LARYA 176_ SICQQ 181_ NGLVP 186_ IVEPE 191_ VIPDG 196_ DHDLE 201_ HCQYV 206_ TEKVL 211_ AAVYK 216_ ALNDH 221_ HVYLE 226_ GTLLK 231_ PNMVT 236_ AGHAC 241_ TKKYT 246_ PEQVA 251_ MATVT 256_ ALHRT 261_ VPAAV 266_ PGICF 271_ LSGGM 276_ SEEDA 281_ TLNLN 286_ AINLC 291_ PLPKP 296_ WKLSF 301_ SYGRA 306_ LQASA 311_ LAAWG 316_ GKAAN 321_ KEATQ 326_ EAFMK 331_ RAMAN 336_ CQAAK 341_ GQYVH 346_ TGSSG 351_ AASTQ 356_SLFTA
1: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)