Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
1_MSAKS 6_ RTIGI 11_ IGAPF 16_ SKGQP 21_ RGGVE 26_ EGPTV 31_ LRKAG 36_ LLEKL 41_ KEQEC 46_ DVKDY 51_ GDLPF 56_ ADIPN 61_ DSPFQ 66_ IVKNP 71_ RSVGK 76_ ASEQL 81_ AGKVA 86_ EVKKN 91_ GRISL 96_ VLGGD 101_ HSLAI 106_ GSISG 111_ HARVH 116_ PDLGV 121_ IWVDA 126_ HTDIN 131_ TPLTT 136_ TSGNL 141_ HGQPV 146_ SFLLK 151_ ELKGK 156_ IPDVP 161_ GFSWV 166_ TPCIS 171_ AKDIV 176_ YIGLR 181_ DVDPG 186_ EHYIL 191_ KTLGI 196_ KYFSM 201_ TEVDR 206_ LGIGK 211_ VMEET 216_ LSYLL 221_ GRKKR 226_ PIHLS 231_ FDVDG 236_ LDPSF 241_ TPATG 246_ TPVVG 251_ GLTYR 256_ EGLYI 261_ TEEIY 266_ KTGLL 271_ SGLDI 276_ MEVNP 281_ SLGKT 286_ PEEVT 291_ RTVNT 296_ AVAIT 301_ LACFG 306_ LAREG 311_ NHKPI 316_DYLNP
1: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys
2: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure