Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
1_MRARP 6_ RPRPL 11_ WATVL 16_ ALGAL 21_ AGVGV 26_ GGPNI 31_ CTTRG 36_ VSSCQ 41_ QCLAV 46_ SPMCA 51_ WCSDE 56_ ALPLG 61_ SPRCD 66_ LKENL 71_ LKDNC 76_ APESI 81_ EFPVS 86_ EARVL 91_ EDRPL 96_ SDKGS 101_ GDSSQ 106_ VTQVS 111_ PQRIA 116_ LRLRP 121_ DDSKN 126_ FSIQV 131_ RQVED 136_ YPVDI 141_ YYLMD 146_ LSYSM 151_ KDDLW 156_ SIQNL 161_ GTKLA 166_ TQMRK 171_ LTSNL 176_ RIGFG 181_ AFVDK 186_ PVSPY 191_ MYISP 196_ PEALE 201_ NPCYD 206_ MKTTC 211_ LPMFG 216_ YKHVL 221_ TLTDQ 226_ VTRFN 231_ EEVKK 236_ QSVSR 241_ NRDAP 246_ EGGFD 251_ AIMQA 256_ TVCDE 261_ KIGWR 266_ NDASH 271_ LLVFT 276_ TDAKT 281_ HIALD 286_ GRLAG 291_ IVQPN 296_ DGQCH 301_ VGSDN 306_ HYSAS 311_ TTMDY 316_ PSLGL 321_ MTEKL 326_ SQKNI 331_ NLIFA 336_ VTENV 341_ VNLYQ 346_ NYSEL 351_ IPGTT 356_ VGVLS 361_ MDSSN 366_ VLQLI 371_ VDAYG 376_ KIRSK 381_ VELEV 386_ RDLPE 391_ ELSLS 396_ FNATC 401_ LNNEV 406_ IPGLK 411_ SCMGL 416_ KIGDT 421_ VSFSI 426_ EAKVR 431_ GCPQE 436_ KEKSF 441_ TIKPV 446_ GFKDS 451_ LIVQV 456_ TFDCD 461_ CACQA 466_ QAEPN 471_ SHRCN 476_ NGNGT 481_ FECGV 486_ CRCGP 491_ GWLGS 496_ QCECS 501_ EEDYR 506_ PSQQD 511_ ECSPR 516_ EGQPV 521_ CSQRG 526_ ECLCG 531_ QCVCH 536_ SSDFG 541_ KITGK 546_ YCECD 551_ DFSCV 556_ RYKGE 561_ MCSGH 566_ GQCSC 571_ GDCLC 576_ DSDWT 581_ GYYCN 586_ CTTRT 591_ DTCMS 596_ SNGLL 601_ CSGRG 606_ KCECG 611_ SCVCI 616_ QPGSY 621_ GDTCE 626_ KCPTC 631_ PDACT 636_ FKKEC 641_ VECKK 646_ FDRGA 651_ LHDEN 656_ TCNRY 661_ CRDEI 666_ ESVKE 671_ LKDTG 676_ KDAVN 681_ CTYKN 686_ EDDCV 691_ VRFQY 696_ YEDSS 701_ GKSIL 706_ YVVEE 711_ PECPK 716_ GPDIL 721_ VVLLS 726_ VMGAI 731_ LLIGL 736_ AALLI 741_ WKLLI 746_ TIHDR 751_ KEFAK 756_ FEEER 761_ ARAKW 766_ DTANN 771_ PLYKE 776_ ATSTF 781_TNITY
1: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428)
2: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8
3: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9
4: (Microbial infection) Acts as a receptor for Hantaan virus
5: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5
6: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus
7: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1
8: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus
9: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions