Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
1_MLGLR 6_ PPLLA 11_ LVGLL 16_ SLGCV 21_ LSQEC 26_ TKFKV 31_ SSCRE 36_ CIESG 41_ PGCTW 46_ CQKLN 51_ FTGPG 56_ DPDSI 61_ RCDTR 66_ PQLLM 71_ RGCAA 76_ DDIMD 81_ PTSLA 86_ ETQED 91_ HNGGQ 96_ KQLSP 101_ QKVTL 106_ YLRPG 111_ QAAAF 116_ NVTFR 121_ RAKGY 126_ PIDLY 131_ YLMDL 136_ SYSML 141_ DDLRN 146_ VKKLG 151_ GDLLR 156_ ALNEI 161_ TESGR 166_ IGFGS 171_ FVDKT 176_ VLPFV 181_ NTHPD 186_ KLRNP 191_ CPNKE 196_ KECQP 201_ PFAFR 206_ HVLKL 211_ TNNSN 216_ QFQTE 221_ VGKQL 226_ ISGNL 231_ DAPEG 236_ GLDAM 241_ MQVAA 246_ CPEEI 251_ GWRNV 256_ TRLLV 261_ FATDD 266_ GFHFA 271_ GDGKL 276_ GAILT 281_ PNDGR 286_ CHLED 291_ NLYKR 296_ SNEFD 301_ YPSVG 306_ QLAHK 311_ LAENN 316_ IQPIF 321_ AVTSR 326_ MVKTY 331_ EKLTE 336_ IIPKS 341_ AVGEL 346_ SEDSS 351_ NVVQL 356_ IKNAY 361_ NKLSS 366_ RVFLD 371_ HNALP 376_ DTLKV 381_ TYDSF 386_ CSNGV 391_ THRNQ 396_ PRGDC 401_ DGVQI 406_ NVPIT 411_ FQVKV 416_ TATEC 421_ IQEQS 426_ FVIRA 431_ LGFTD 436_ IVTVQ 441_ VLPQC 446_ ECRCR 451_ DQSRD 456_ RSLCH 461_ GKGFL 466_ ECGIC 471_ RCDTG 476_ YIGKN 481_ CECQT 486_ QGRSS 491_ QELEG 496_ SCRKD 501_ NNSII 506_ CSGLG 511_ DCVCG 516_ QCLCH 521_ TSDVP 526_ GKLIY 531_ GQYCE 536_ CDTIN 541_ CERYN 546_ GQVCG 551_ GPGRG 556_ LCFCG 561_ KCRCH 566_ PGFEG 571_ SACQC 576_ ERTTE 581_ GCLNP 586_ RRVEC 591_ SGRGR 596_ CRCNV 601_ CECHS 606_ GYQLP 611_ LCQEC 616_ PGCPS 621_ PCGKY 626_ ISCAE 631_ CLKFE 636_ KGPFG 641_ KNCSA 646_ ACPGL 651_ QLSNN 656_ PVKGR 661_ TCKER 666_ DSEGC 671_ WVAYT 676_ LEQQD 681_ GMDRY 686_ LIYVD 691_ ESREC 696_ VAGPN 701_ IAAIV 706_ GGTVA 711_ GIVLI 716_ GILLL 721_ VIWKA 726_ LIHLS 731_ DLREY 736_ RRFEK 741_ EKLKS 746_ QWNND 751_ NPLFK 756_ SATTT 761_VMNPK
1: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407)