Inhibin alpha chain
1_MVLHL 6_ LLFLL 11_ LTPQG 16_ GHSCQ 21_ GLELA 26_ RELVL 31_ AKVRA 36_ LFLDA 41_ LGPPA 46_ VTREG 51_ GDPGV 56_ RRLPR 61_ RHALG 66_ GFTHR 71_ GSEPE 76_ EEEDV 81_ SQAIL 86_ FPATD 91_ ASCED 96_ KSAAR 101_ GLAQE 106_ AEEGL 111_ FRYMF 116_ RPSQH 121_ TRSRQ 126_ VTSAQ 131_ LWFHT 136_ GLDRQ 141_ GTAAS 146_ NSSEP 151_ LLGLL 156_ ALSPG 161_ GPVAV 166_ PMSLG 171_ HAPPH 176_ WAVLH 181_ LATSA 186_ LSLLT 191_ HPVLV 196_ LLLRC 201_ PLCTC 206_ SARPE 211_ ATPFL 216_ VAHTR 221_ TRPPS 226_ GGERA 231_ RRSTP 236_ LMSWP 241_ WSPSA 246_ LRLLQ 251_ RPPEE 256_ PAAHA 261_ NCHRV 266_ ALNIS 271_ FQELG 276_ WERWI 281_ VYPPS 286_ FIFHY 291_ CHGGC 296_ GLHIP 301_ PNLSL 306_ PVPGA 311_ PPTPA 316_ QPYSL 321_ LPGAQ 326_ PCCAA 331_ LPGTM 336_ RPLHV 341_ RTTSD 346_ GGYSF 351_ KYETV 356_ PNLLT 361_QHCAC
1: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins
2: Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor
3: Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (PubMed:34910520)