Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
1_MRMLL 6_ HLSLL 11_ ALGAA 16_ YVYAI 21_ PTEIP 26_ TSALV 31_ KETLA 36_ LLSTH 41_ RTLLI 46_ ANETL 51_ RIPVP 56_ VHKNH 61_ QLCTE 66_ EIFQG 71_ IGTLE 76_ SQTVQ 81_ GGTVE 86_ RLFKN 91_ LSLIK 96_ KYIDG 101_ QKKKC 106_ GEERR 111_ RVNQF 116_ LDYLQ 121_ EFLGV 126_MNTEW
1: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138)