Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
1_MQMSP 6_ ALTCL 11_ VLGLA 16_ LVFGE 21_ GSAVH 26_ HPPSY 31_ VAHLA 36_ SDFGV 41_ RVFQQ 46_ VAQAS 51_ KDRNV 56_ VFSPY 61_ GVASV 66_ LAMLQ 71_ LTTGG 76_ ETQQQ 81_ IQAAM 86_ GFKID 91_ DKGMA 96_ PALRH 101_ LYKEL 106_ MGPWN 111_ KDEIS 116_ TTDAI 121_ FVQRD 126_ LKLVQ 131_ GFMPH 136_ FFRLF 141_ RSTVK 146_ QVDFS 151_ EVERA 156_ RFIIN 161_ DWVKT 166_ HTKGM 171_ ISNLL 176_ GKGAV 181_ DQLTR 186_ LVLVN 191_ ALYFN 196_ GQWKT 201_ PFPDS 206_ STHRR 211_ LFHKS 216_ DGSTV 221_ SVPMM 226_ AQTNK 231_ FNYTE 236_ FTTPD 241_ GHYYD 246_ ILELP 251_ YHGDT 256_ LSMFI 261_ AAPYE 266_ KEVPL 271_ SALTN 276_ ILSAQ 281_ LISHW 286_ KGNMT 291_ RLPRL 296_ LVLPK 301_ FSLET 306_ EVDLR 311_ KPLEN 316_ LGMTD 321_ MFRQF 326_ QADFT 331_ SLSDQ 336_ EPLHV 341_ AQALQ 346_ KVKIE 351_ VNESG 356_ TVASS 361_ STAVI 366_ VSARM 371_ APEEI 376_ IMDRP 381_ FLFVV 386_ RHNPT 391_ GTVLF 396_MGQVM
1: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084)