Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)
1_MASRL 6_ TLLTL 11_ LLLLL 16_ AGDRA 21_ SSNPN 26_ ATSSS 31_ SQDPE 36_ SLQDR 41_ GEGKV 46_ ATTVI 51_ SKMLF 56_ VEPIL 61_ EVSSL 66_ PTTNS 71_ TTNSA 76_ TKITA 81_ NTTDE 86_ PTTQP 91_ TTEPT 96_ TQPTI 101_ QPTQP 106_ TTQLP 111_ TDSPT 116_ QPTTG 121_ SFCPG 126_ PVTLC 131_ SDLES 136_ HSTEA 141_ VLGDA 146_ LVDFS 151_ LKLYH 156_ AFSAM 161_ KKVET 166_ NMAFS 171_ PFSIA 176_ SLLTQ 181_ VLLGA 186_ GENTK 191_ TNLES 196_ ILSYP 201_ KDFTC 206_ VHQAL 211_ KGFTT 216_ KGVTS 221_ VSQIF 226_ HSPDL 231_ AIRDT 236_ FVNAS 241_ RTLYS 246_ SSPRV 251_ LSNNS 256_ DANLE 261_ LINTW 266_ VAKNT 271_ NNKIS 276_ RLLDS 281_ LPSDT 286_ RLVLL 291_ NAIYL 296_ SAKWK 301_ TTFDP 306_ KKTRM 311_ EPFHF 316_ KNSVI 321_ KVPMM 326_ NSKKY 331_ PVAHF 336_ IDQTL 341_ KAKVG 346_ QLQLS 351_ HNLSL 356_ VILVP 361_ QNLKH 366_ RLEDM 371_ EQALS 376_ PSVFK 381_ AIMEK 386_ LEMSK 391_ FQPTL 396_ LTLPR 401_ IKVTT 406_ SQDML 411_ SIMEK 416_ LEFFD 421_ FSYDL 426_ NLCGL 431_ TEDPD 436_ LQVSA 441_ MQHQT 446_ VLELT 451_ ETGVE 456_ AAAAS 461_ AISVA 466_ RTLLV 471_ FEVQQ 476_ PFLFV 481_ LWDQQ 486_ HKFPV 491_FMGRV
1: Serine protease inhibitor, which acrs as a regulator of the classical complement pathway (PubMed:10946292, PubMed:11527969, PubMed:3458172, PubMed:6416294). Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases (PubMed:10946292, PubMed:3458172, PubMed:6416294). May also regulate blood coagulation, fibrinolysis and the generation of kinins (PubMed:8495195). Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein (PubMed:8495195)