Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
1_MGVPF 6_ FSSLR 11_ CMVDL 16_ GPCWA 21_ GGLTA 26_ EMKLL 31_ LALAG 36_ LLAIL 41_ ATPQP 46_ SEGAA 51_ PAVLG 56_ EVDTS 61_ LVLSS 66_ MEEAK 71_ QLVDK 76_ AYKER 81_ RESIK 86_ QRLRS 91_ GSASP 96_ MELLS 101_ YFKQP 106_ VAATR 111_ TAVRA 116_ ADYLH 121_ VALDL 126_ LERKL 131_ RSLWR 136_ RPFNV 141_ TDVLT 146_ PAQLN 151_ VLSKS 156_ SGCAY 161_ QDVGV 166_ TCPEQ 171_ DKYRT 176_ ITGMC 181_ NNRRS 186_ PTLGA 191_ SNRAF 196_ VRWLP 201_ AEYED 206_ GFSLP 211_ YGWTP 216_ GVKRN 221_ GFPVA 226_ LARAV 231_ SNEIV 236_ RFPTD 241_ QLTPD 246_ QERSL 251_ MFMQW 256_ GQLLD 261_ HDLDF 266_ TPEPA 271_ ARASF 276_ VTGVN 281_ CETSC 286_ VQQPP 291_ CFPLK 296_ IPPND 301_ PRIKN 306_ QADCI 311_ PFFRS 316_ CPACP 321_ GSNIT 326_ IRNQI 331_ NALTS 336_ FVDAS 341_ MVYGS 346_ EEPLA 351_ RNLRN 356_ MSNQL 361_ GLLAV 366_ NQRFQ 371_ DNGRA 376_ LLPFD 381_ NLHDD 386_ PCLLT 391_ NRSAR 396_ IPCFL 401_ AGDTR 406_ SSEMP 411_ ELTSM 416_ HTLLL 421_ REHNR 426_ LATEL 431_ KSLNP 436_ RWDGE 441_ RLYQE 446_ ARKIV 451_ GAMVQ 456_ IITYR 461_ DYLPL 466_ VLGPT 471_ AMRKY 476_ LPTYR 481_ SYNDS 486_ VDPRI 491_ ANVFT 496_ NAFRY 501_ GHTLI 506_ QPFMF 511_ RLDNR 516_ YQPME 521_ PNPRV 526_ PLSRV 531_ FFASW 536_ RVVLE 541_ GGIDP 546_ ILRGL 551_ MATPA 556_ KLNRQ 561_ NQIAV 566_ DEIRE 571_ RLFEQ 576_ VMRIG 581_ LDLPA 586_ LNMQR 591_ SRDHG 596_ LPGYN 601_ AWRRF 606_ CGLPQ 611_ PETVG 616_ QLGTV 621_ LRNLK 626_ LARKL 631_ MEQYG 636_ TPNNI 641_ DIWMG 646_ GVSEP 651_ LKRKG 656_ RVGPL 661_ LACII 666_ GTQFR 671_ KLRDG 676_ DRFWW 681_ ENEGV 686_ FSMQQ 691_ RQALA 696_ QISLP 701_ RIICD 706_ NTGIT 711_ TVSKN 716_ NIFMS 721_ NSYPR 726_ DFVNC 731_ STLPA 736_LNLAS
1: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971)