Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)
1_MSALG 6_ VTVAL 11_ LVWAA 16_ FLLLV 21_ SMWRQ 26_ VHSSW 31_ NLPPG 36_ PFPLP 41_ IIGNL 46_ FQLEL 51_ KNIPK 56_ SFTRL 61_ AQRFG 66_ PVFTL 71_ YVGSQ 76_ RMVVM 81_ HGYKA 86_ VKEAL 91_ LDYKD 96_ EFSGR 101_ GDLPA 106_ FHAHR 111_ DRGII 116_ FNNGP 121_ TWKDI 126_ RRFSL 131_ TTLRN 136_ YGMGK 141_ QGNES 146_ RIQRE 151_ AHFLL 156_ EALRK 161_ TQGQP 166_ FDPTF 171_ LIGCA 176_ PCNVI 181_ ADILF 186_ RKHFD 191_ YNDEK 196_ FLRLM 201_ YLFNE 206_ NFHLL 211_ STPWL 216_ QLYNN 221_ FPSFL 226_ HYLPG 231_ SHRKV 236_ IKNVA 241_ EVKEY 246_ VSERV 251_ KEHHQ 256_ SLDPN 261_ CPRDL 266_ TDCLL 271_ VEMEK 276_ EKHSA 281_ ERLYT 286_ MDGIT 291_ VTVAD 296_ LFFAG 301_ TETTS 306_ TTLRY 311_ GLLIL 316_ MKYPE 321_ IEEKL 326_ HEEID 331_ RVIGP 336_ SRIPA 341_ IKDRQ 346_ EMPYM 351_ DAVVH 356_ EIQRF 361_ ITLVP 366_ SNLPH 371_ EATRD 376_ TIFRG 381_ YLIPK 386_ GTVVV 391_ PTLDS 396_ VLYDN 401_ QEFPD 406_ PEKFK 411_ PEHFL 416_ NENGK 421_ FKYSD 426_ YFKPF 431_ STGKR 436_ VCAGE 441_ GLARM 446_ ELFLL 451_ LCAIL 456_ QHFNL 461_ KPLVD 466_ PKDID 471_ LSPIH 476_ IGFGC 481_ IPPRY 486_KLCVI
1: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable)