Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)
1_MAEGE 6_ ITTFT 11_ ALTEK 16_ FNLPP 21_ GNYKK 26_ PKLLY 31_ CSNGG 36_ HFLRI 41_ LPDGT 46_ VDGTR 51_ DRSDQ 56_ HIQLQ 61_ LSAES 66_ VGEVY 71_ IKSTE 76_ TGQYL 81_ AMDTD 86_ GLLYG 91_ SQTPN 96_ EECLF 101_ LERLE 106_ ENHYN 111_ TYISK 116_ KHAEK 121_ NWFVG 126_ LKKNG 131_ SCKRG 136_ PRTHY 141_ GQKAI 146_LFLPL
1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107)