Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]
1_MDYLL 6_ MIFSL 11_ LFVAC 16_ QGAPE 21_ TAVLG 26_ AELSA 31_ VGENG 36_ GEKPT 41_ PSPPW 46_ RLRRS 51_ KRCSC 56_ SSLMD 61_ KECVY 66_ FCHLD 71_ IIWVN 76_ TPEHV 81_ VPYGL 86_ GSPRS 91_ KRALE 96_ NLLPT 101_ KATDR 106_ ENRCQ 111_ CASQK 116_ DKKCW 121_ NFCQA 126_ GKELR 131_ AEDIM 136_ EKDWN 141_ NHKKG 146_ KDCSK 151_ LGKKC 156_ IYQQL 161_ VRGRK 166_ IRRSS 171_ EEHLR 176_ QTRSE 181_ TMRNS 186_ VKSSF 191_ HDPKL 196_ KGKPS 201_ RERYV 206_THNRA
1: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity)