Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]
1_MVSRM 6_ VSTML 11_ SGLLF 16_ WLASG 21_ WTPAF 26_ AYSPR 31_ TPDRV 36_ SEADI 41_ QRLLH 46_ GVMEQ 51_ LGIAR 56_ PRVEY 61_ PAHQA 66_ MNLVG 71_ PQSIE 76_ GGAHE 81_ GLQHL 86_ GPFGN 91_ IPNIV 96_ AELTG 101_ DNIPK 106_ DFSED 111_ QGYPD 116_ PPNPC 121_ PVGKT 126_ ADDGC 131_ LENTP 136_ DTAEF 141_ SREFQ 146_ LHQHL 151_ FDPEH 156_ DYPGL 161_ GKWNK 166_ KLLYE 171_ KMKGG 176_ ERRKR 181_ RSVNP 186_ YLQGQ 191_ RLDNV 196_ VAKKS 201_ VPHFS 206_DEDKD
1: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro