Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
1_MTAKM 6_ ETTFY 11_ DDALN 16_ ASFLP 21_ SESGP 26_ YGYSN 31_ PKILK 36_ QSMTL 41_ NLADP 46_ VGSLK 51_ PHLRA 56_ KNSDL 61_ LTSPD 66_ VGLLK 71_ LASPE 76_ LERLI 81_ IQSSN 86_ GHITT 91_ TPTPT 96_ QFLCP 101_ KNVTD 106_ EQEGF 111_ AEGFV 116_ RALAE 121_ LHSQN 126_ TLPSV 131_ TSAAQ 136_ PVNGA 141_ GMVAP 146_ AVASV 151_ AGGSG 156_ SGGFS 161_ ASLHS 166_ EPPVY 171_ ANLSN 176_ FNPGA 181_ LSSGG 186_ GAPSY 191_ GAAGL 196_ AFPAQ 201_ PQQQQ 206_ QPPHH 211_ LPQQM 216_ PVQHP 221_ RLQAL 226_ KEEPQ 231_ TVPEM 236_ PGETP 241_ PLSPI 246_ DMESQ 251_ ERIKA 256_ ERKRM 261_ RNRIA 266_ ASKCR 271_ KRKLE 276_ RIARL 281_ EEKVK 286_ TLKAQ 291_ NSELA 296_ STANM 301_ LREQV 306_ AQLKQ 311_ KVMNH 316_ VNSGC 321_ QLMLT 326_QQLQT
1: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306)
2: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression