DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)
1_MSEGN 6_ AAGEP 11_ STPGG 16_ PRPLL 21_ TGARG 26_ LIGRR 31_ PAPPL 36_ TPGRL 41_ PSIRS 46_ RDLTL 51_ GGVKK 56_ KTFTP 61_ NIISR 66_ KIKEE 71_ PKEEV 76_ TVKKE 81_ KRERD 86_ RDRQR 91_ EGHGR 96_ GRGRP 101_ EVIQS 106_ HSIFE 111_ QGPAE 116_ MMKKK 121_ GNWDK 126_ TVDVS 131_ DMGPS 136_ HIINI 141_ KKEKR 146_ ETDEE 151_ TKQIL 156_ RMLEK 161_ DDFLD 166_ DPGLR 171_ NDTRN 176_ MPVQL 181_ PLAHS 186_ GWLFK 191_ EENDE 196_ PDVKP 201_ WLAGP 206_ KEEDM 211_ EVDIP 216_ AVKVK 221_ EEPRD 226_ EEEEA 231_ KMKAP 236_ PKAAR 241_ KTPGL 246_ PKDVS 251_ VAELL 256_ RELSL 261_ TKEEE 266_ LLFLQ 271_ LPDTL 276_ PGQPP 281_ TQDIK 286_ PIKTE 291_ VQGED 296_ GQVVL 301_ IKQEK 306_ DREAK 311_ LAENA 316_ CTLAD 321_ LTEGQ 326_ VGKLL 331_ IRKSG 336_ RVQLL 341_ LGKVT 346_ LDVTM 351_ GTACS 356_ FLQEL 361_ VSVGL 366_ GDSRT 371_ GEMTV 376_ LGHVK 381_ HKLVC 386_ SPDFE 391_SLLDH
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370)