ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 1) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c)
1_MQTAG 6_ ALFIS 11_ PALIR 16_ CCTRG 21_ LIRPV 26_ SASFL 31_ NSPVN 36_ SSKQP 41_ SYSNF 46_ PLQVA 51_ RREFQ 56_ TSVVS 61_ RDIDT 66_ AAKFI 71_ GAGAA 76_ TVGVA 81_ GSGAG 86_ IGTVF 91_ GSLII 96_ GYARN 101_ PSLKQ 106_ QLFSY 111_ AILGF 116_ ALSEA 121_ MGLFC 126_ LMVAF 131_LILFA
1: Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix (PubMed:37244256). Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism (PubMed:37244256)