Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)
1_MKHSL 6_ NALLI 11_ FLIIT 16_ SAWGG 21_ SKGPL 26_ DQLEK 31_ GGETA 36_ QSADP 41_ QWEQL 46_ NNKNL 51_ SMPLL 56_ PADFH 61_ KENTV 66_ TNDWI 71_ PEGEE 76_ DDDYL 81_ DLEKI 86_ FSEDD 91_ DYIDI 96_ VDSLS 101_ VSPTD 106_ SDVSA 111_ GNILQ 116_ LFHGK 121_ SRIQR 126_ LNILN 131_ AKFAF 136_ NLYRV 141_ LKDQV 146_ NTFDN 151_ IFIAP 156_ VGIST 161_ AMGMI 166_ SLGLK 171_ GETHE 176_ QVHSI 181_ LHFKD 186_ FVNAS 191_ SKYEI 196_ TTIHN 201_ LFRKL 206_ THRLF 211_ RRNFG 216_ YTLRS 221_ VNDLY 226_ IQKQF 231_ PILLD 236_ FKTKV 241_ REYYF 246_ AEAQI 251_ ADFSD 256_ PAFIS 261_ KTNNH 266_ IMKLT 271_ KGLIK 276_ DALEN 281_ IDPAT 286_ QMMIL 291_ NCIYF 296_ KGSWV 301_ NKFPV 306_ EMTHN 311_ HNFRL 316_ NEREV 321_ VKVSM 326_ MQTKG 331_ NFLAA 336_ NDQEL 341_ DCDIL 346_ QLEYV 351_ GGISM 356_ LIVVP 361_ HKMSG 366_ MKTLE 371_ AQLTP 376_ RVVER 381_ WQKSM 386_ TNRTR 391_ EVLLP 396_ KFKLE 401_ KNYNL 406_ VESLK 411_ LMGIR 416_ MLFDK 421_ NGNMA 426_ GISDQ 431_ RIAID 436_ LFKHQ 441_ GTITV 446_ NEEGT 451_ QATTV 456_ TTVGF 461_ MPLST 466_ QVRFT 471_ VDRPF 476_ LFLIY 481_ EHRTS 486_ CLLFM 491_GRVAN
1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner
2: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils
3: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro