Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
1_MLWKL 6_ TDNIK 11_ YEDCE 16_ DRHDG 21_ TSNGT 26_ ARLPQ 31_ LGTVG 36_ QSPYT 41_ SAPPL 46_ SHTPN 51_ ADFQP 56_ PYFPP 61_ PYQPI 66_ YPQSQ 71_ DPYSH 76_ VNDPY 81_ SLNPL 86_ HAQPQ 91_ PQHPG 96_ WPGQR 101_ QSQES 106_ GLLHT 111_ HRGLP 116_ HQLSG 121_ LDPRR 126_ DYRRH 131_ EDLLH 136_ GPHAL 141_ SSGLG 146_ DLSIH 151_ SLPHA 156_ IEEVP 161_ HVEDP 166_ GINIP 171_ DQTVI 176_ KKGPV 181_ SLSKS 186_ NSNAV 191_ SAIPI 196_ NKDNL 201_ FGGVV 206_ NPNEV 211_ FCSVP 216_ GRLSL 221_ LSSTS 226_ KYKVT 231_ VAEVQ 236_ RRLSP 241_ PECLN 246_ ASLLG 251_ GVLRR 256_ AKSKN 261_ GGRSL 266_ REKLD 271_ KIGLN 276_ LPAGR 281_ RKAAN 286_ VTLLT 291_ SLVEG 296_ EAVHL 301_ ARDFG 306_ YVCET 311_ EFPAK 316_ AVAEF 321_ LNRQH 326_ SDPNE 331_ QVTRK 336_ NMLLA 341_ TKQIC 346_ KEFTD 351_ LLAQD 356_ RSPLG 361_ NSRPN 366_ PILEP 371_ GIQSC 376_ LTHFN 381_ LISHG 386_ FGSPA 391_ VCAAV 396_ TALQN 401_ YLTEA 406_ LKAMD 411_ KMYLS 416_ NNPNS 421_ HTDNN 426_ AKSSD 431_KEEKH
1: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region