Gene name: KRT18

Uniprot entry:

P05783

Protein names:

Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)

Protein sequence:

1_MSFTT 6_ RSTFS 11_ TNYRS 16_ LGSVQ 21_ APSYG 26_ ARPVS 31_ SAASV 36_ YAGAG 41_ GSGSR 46_ ISVSR 51_ STSFR 56_ GGMGS 61_ GGLAT 66_ GIAGG 71_ LAGMG 76_ GIQNE 81_ KETMQ 86_ SLNDR 91_ LASYL 96_ DRVRS 101_ LETEN 106_ RRLES 111_ KIREH 116_ LEKKG 121_ PQVRD 126_ WSHYF 131_ KIIED 136_ LRAQI 141_ FANTV 146_ DNARI 151_ VLQID 156_ NARLA 161_ ADDFR 166_ VKYET 171_ ELAMR 176_ QSVEN 181_ DIHGL 186_ RKVID 191_ DTNIT 196_ RLQLE 201_ TEIEA 206_ LKEEL 211_ LFMKK 216_ NHEEE 221_ VKGLQ 226_ AQIAS 231_ SGLTV 236_ EVDAP 241_ KSQDL 246_ AKIMA 251_ DIRAQ 256_ YDELA 261_ RKNRE 266_ ELDKY 271_ WSQQI 276_ EESTT 281_ VVTTQ 286_ SAEVG 291_ AAETT 296_ LTELR 301_ RTVQS 306_ LEIDL 311_ DSMRN 316_ LKASL 321_ ENSLR 326_ EVEAR 331_ YALQM 336_ EQLNG 341_ ILLHL 346_ ESELA 351_ QTRAE 356_ GQRQA 361_ QEYEA 366_ LLNIK 371_ VKLEA 376_ EIATY 381_ RRLLE 386_ DGEDF 391_ NLGDA 396_ LDSSN 401_ SMQTI 406_ QKTTT 411_ RRIVD 416_ GKVVS 421_ETNDT

Protein annotations

Protein functions:

1: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection