Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]
1_MAQKE 6_ GGRTV 11_ PCCSR 16_ PKVAA 21_ LTAGT 26_ LLLLT 31_ AIGAA 36_ SWAIV 41_ AVLLR 46_ SDQEP 51_ LYPVQ 56_ VSSAD 61_ ARLMV 66_ FDKTE 71_ GTWRL 76_ LCSSR 81_ SNARV 86_ AGLSC 91_ EEMGF 96_ LRALT 101_ HSELD 106_ VRTAG 111_ ANGTS 116_ GFFCV 121_ DEGRL 126_ PHTQR 131_ LLEVI 136_ SVCDC 141_ PRGRF 146_ LAAIC 151_ QDCGR 156_ RKLPV 161_ DRIVG 166_ GRDTS 171_ LGRWP 176_ WQVSL 181_ RYDGA 186_ HLCGG 191_ SLLSG 196_ DWVLT 201_ AAHCF 206_ PERNR 211_ VLSRW 216_ RVFAG 221_ AVAQA 226_ SPHGL 231_ QLGVQ 236_ AVVYH 241_ GGYLP 246_ FRDPN 251_ SEENS 256_ NDIAL 261_ VHLSS 266_ PLPLT 271_ EYIQP 276_ VCLPA 281_ AGQAL 286_ VDGKI 291_ CTVTG 296_ WGNTQ 301_ YYGQQ 306_ AGVLQ 311_ EARVP 316_ IISND 321_ VCNGA 326_ DFYGN 331_ QIKPK 336_ MFCAG 341_ YPEGG 346_ IDACQ 351_ GDSGG 356_ PFVCE 361_ DSISR 366_ TPRWR 371_ LCGIV 376_ SWGTG 381_ CALAQ 386_ KPGVY 391_ TKVSD 396_ FREWI 401_ FQAIK 406_ THSEA 411_SGMVT
1: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890)