T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)
1_MPMGS 6_ LQPLA 11_ TLYLL 16_ GMLVA 21_ SCLGR 26_ LSWYD 31_ PDFQA 36_ RLTRS 41_ NSKCQ 46_ GQLEV 51_ YLKDG 56_ WHMVC 61_ SQSWG 66_ RSSKQ 71_ WEDPS 76_ QASKV 81_ CQRLN 86_ CGVPL 91_ SLGPF 96_ LVTYT 101_ PQSSI 106_ ICYGQ 111_ LGSFS 116_ NCSHS 121_ RNDMC 126_ HSLGL 131_ TCLEP 136_ QKTTP 141_ PTTRP 146_ PPTTT 151_ PEPTA 156_ PPRLQ 161_ LVAQS 166_ GGQHC 171_ AGVVE 176_ FYSGS 181_ LGGTI 186_ SYEAQ 191_ DKTQD 196_ LENFL 201_ CNNLQ 206_ CGSFL 211_ KHLPE 216_ TEAGR 221_ AQDPG 226_ EPREH 231_ QPLPI 236_ QWKIQ 241_ NSSCT 246_ SLEHC 251_ FRKIK 256_ PQKSG 261_ RVLAL 266_ LCSGF 271_ QPKVQ 276_ SRLVG 281_ GSSIC 286_ EGTVE 291_ VRQGA 296_ QWAAL 301_ CDSSS 306_ ARSSL 311_ RWEEV 316_ CREQQ 321_ CGSVN 326_ SYRVL 331_ DAGDP 336_ TSRGL 341_ FCPHQ 346_ KLSQC 351_ HELWE 356_ RNSYC 361_ KKVFV 366_ TCQDP 371_ NPAGL 376_ AAGTV 381_ ASIIL 386_ ALVLL 391_ VVLLV 396_ VCGPL 401_ AYKKL 406_ VKKFR 411_ QKKQR 416_ QWIGP 421_ TGMNQ 426_ NMSFH 431_ RNHTA 436_ TVRSH 441_ AENPT 446_ ASHVD 451_ NEYSQ 456_ PPRNS 461_ HLSAY 466_ PALEG 471_ ALHRS 476_ SMQPD 481_ NSSDS 486_DYDLH
1: Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044)