Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37)
1_MEANG 6_ LGPQG 11_ FPELK 16_ NDTFL 21_ RAAWG 26_ EETDY 31_ TPVWC 36_ MRQAG 41_ RYLPE 46_ FRETR 51_ AAQDF 56_ FSTCR 61_ SPEAC 66_ CELTL 71_ QPLRR 76_ FPLDA 81_ AIIFS 86_ DILVV 91_ PQALG 96_ MEVTM 101_ VPGKG 106_ PSFPE 111_ PLREE 116_ QDLER 121_ LRDPE 126_ VVASE 131_ LGYVF 136_ QAITL 141_ TRQRL 146_ AGRVP 151_ LIGFA 156_ GAPWT 161_ LMTYM 166_ VEGGG 171_ SSTMA 176_ QAKRW 181_ LYQRP 186_ QASHQ 191_ LLRIL 196_ TDALV 201_ PYLVG 206_ QVVAG 211_ AQALQ 216_ LFESH 221_ AGHLG 226_ PQLFN 231_ KFALP 236_ YIRDV 241_ AKQVK 246_ ARLRE 251_ AGLAP 256_ VPMII 261_ FAKDG 266_ HFALE 271_ ELAQA 276_ GYEVV 281_ GLDWT 286_ VAPKK 291_ ARECV 296_ GKTVT 301_ LQGNL 306_ DPCAL 311_ YASEE 316_ EIGQL 321_ VKQML 326_ DDFGP 331_ HRYIA 336_ NLGHG 341_ LYPDM 346_ DPEHV 351_ GAFVD 356_ AVHKH 361_SRLLR
1: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824)