UDP-glucuronosyltransferase 2B4 (UDPGT 2B4) (UGT2B4) (EC 2.4.1.17) (HLUG25) (Hyodeoxycholic acid-specific UDPGT) (UDPGTh-1)
1_MSMKW 6_ TSALL 11_ LIQLS 16_ CYFSS 21_ GSCGK 26_ VLVWP 31_ TEFSH 36_ WMNIK 41_ TILDE 46_ LVQRG 51_ HEVTV 56_ LASSA 61_ SISFD 66_ PNSPS 71_ TLKFE 76_ VYPVS 81_ LTKTE 86_ FEDII 91_ KQLVK 96_ RWAEL 101_ PKDTF 106_ WSYFS 111_ QVQEI 116_ MWTFN 121_ DILRK 126_ FCKDI 131_ VSNKK 136_ LMKKL 141_ QESRF 146_ DVVLA 151_ DAVFP 156_ FGELL 161_ AELLK 166_ IPFVY 171_ SLRFS 176_ PGYAI 181_ EKHSG 186_ GLLFP 191_ PSYVP 196_ VVMSE 201_ LSDQM 206_ TFIER 211_ VKNMI 216_ YVLYF 221_ EFWFQ 226_ IFDMK 231_ KWDQF 236_ YSEVL 241_ GRPTT 246_ LSETM 251_ AKADI 256_ WLIRN 261_ YWDFQ 266_ FPHPL 271_ LPNVE 276_ FVGGL 281_ HCKPA 286_ KPLPK 291_ EMEEF 296_ VQSSG 301_ ENGVV 306_ VFSLG 311_ SMVSN 316_ TSEER 321_ ANVIA 326_ SALAK 331_ IPQKV 336_ LWRFD 341_ GNKPD 346_ TLGLN 351_ TRLYK 356_ WIPQN 361_ DLLGH 366_ PKTRA 371_ FITHG 376_ GANGI 381_ YEAIY 386_ HGIPM 391_ VGVPL 396_ FADQP 401_ DNIAH 406_ MKAKG 411_ AAVSL 416_ DFHTM 421_ SSTDL 426_ LNALK 431_ TVIND 436_ PLYKE 441_ NAMKL 446_ SRIHH 451_ DQPVK 456_ PLDRA 461_ VFWIE 466_ FVMRH 471_ KGAKH 476_ LRVAA 481_ HDLTW 486_ FQYHS 491_ LDVTG 496_ FLLAC 501_ VATVI 506_ FIITK 511_ CLFCV 516_ WKFVR 521_TGKKG
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867)