Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
1_MGCVQ 6_ CKDKE 11_ ATKLT 16_ EERDG 21_ SLNQS 26_ SGYRY 31_ GTDPT 36_ PQHYP 41_ SFGVT 46_ SIPNY 51_ NNFHA 56_ AGGQG 61_ LTVFG 66_ GVNSS 71_ SHTGT 76_ LRTRG 81_ GTGVT 86_ LFVAL 91_ YDYEA 96_ RTEDD 101_ LSFHK 106_ GEKFQ 111_ ILNSS 116_ EGDWW 121_ EARSL 126_ TTGET 131_ GYIPS 136_ NYVAP 141_ VDSIQ 146_ AEEWY 151_ FGKLG 156_ RKDAE 161_ RQLLS 166_ FGNPR 171_ GTFLI 176_ RESET 181_ TKGAY 186_ SLSIR 191_ DWDDM 196_ KGDHV 201_ KHYKI 206_ RKLDN 211_ GGYYI 216_ TTRAQ 221_ FETLQ 226_ QLVQH 231_ YSERA 236_ AGLCC 241_ RLVVP 246_ CHKGM 251_ PRLTD 256_ LSVKT 261_ KDVWE 266_ IPRES 271_ LQLIK 276_ RLGNG 281_ QFGEV 286_ WMGTW 291_ NGNTK 296_ VAIKT 301_ LKPGT 306_ MSPES 311_ FLEEA 316_ QIMKK 321_ LKHDK 326_ LVQLY 331_ AVVSE 336_ EPIYI 341_ VTEYM 346_ NKGSL 351_ LDFLK 356_ DGEGR 361_ ALKLP 366_ NLVDM 371_ AAQVA 376_ AGMAY 381_ IERMN 386_ YIHRD 391_ LRSAN 396_ ILVGN 401_ GLICK 406_ IADFG 411_ LARLI 416_ EDNEY 421_ TARQG 426_ AKFPI 431_ KWTAP 436_ EAALY 441_ GRFTI 446_ KSDVW 451_ SFGIL 456_ LTELV 461_ TKGRV 466_ PYPGM 471_ NNREV 476_ LEQVE 481_ RGYRM 486_ PCPQD 491_ CPISL 496_ HELMI 501_ HCWKK 506_ DPEER 511_ PTFEY 516_ LQSFL 521_ EDYFT 526_ ATEPQ 531_YQPGE
1: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798)