Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
1_MPPKT 6_ PRKTA 11_ ATAAA 16_ AAAEP 21_ PAPPP 26_ PPPPE 31_ EDPEQ 36_ DSGPE 41_ DLPLV 46_ RLEFE 51_ ETEEP 56_ DFTAL 61_ CQKLK 66_ IPDHV 71_ RERAW 76_ LTWEK 81_ VSSVD 86_ GVLGG 91_ YIQKK 96_ KELWG 101_ ICIFI 106_ AAVDL 111_ DEMSF 116_ TFTEL 121_ QKNIE 126_ ISVHK 131_ FFNLL 136_ KEIDT 141_ STKVD 146_ NAMSR 151_ LLKKY 156_ DVLFA 161_ LFSKL 166_ ERTCE 171_ LIYLT 176_ QPSSS 181_ ISTEI 186_ NSALV 191_ LKVSW 196_ ITFLL 201_ AKGEV 206_ LQMED 211_ DLVIS 216_ FQLML 221_ CVLDY 226_ FIKLS 231_ PPMLL 236_ KEPYK 241_ TAVIP 246_ INGSP 251_ RTPRR 256_ GQNRS 261_ ARIAK 266_ QLEND 271_ TRIIE 276_ VLCKE 281_ HECNI 286_ DEVKN 291_ VYFKN 296_ FIPFM 301_ NSLGL 306_ VTSNG 311_ LPEVE 316_ NLSKR 321_ YEEIY 326_ LKNKD 331_ LDARL 336_ FLDHD 341_ KTLQT 346_ DSIDS 351_ FETQR 356_ TPRKS 361_ NLDEE 366_ VNVIP 371_ PHTPV 376_ RTVMN 381_ TIQQL 386_ MMILN 391_ SASDQ 396_ PSENL 401_ ISYFN 406_ NCTVN 411_ PKESI 416_ LKRVK 421_ DIGYI 426_ FKEKF 431_ AKAVG 436_ QGCVE 441_ IGSQR 446_ YKLGV 451_ RLYYR 456_ VMESM 461_ LKSEE 466_ ERLSI 471_ QNFSK 476_ LLNDN 481_ IFHMS 486_ LLACA 491_ LEVVM 496_ ATYSR 501_ STSQN 506_ LDSGT 511_ DLSFP 516_ WILNV 521_ LNLKA 526_ FDFYK 531_ VIESF 536_ IKAEG 541_ NLTRE 546_ MIKHL 551_ ERCEH 556_ RIMES 561_ LAWLS 566_ DSPLF 571_ DLIKQ 576_ SKDRE 581_ GPTDH 586_ LESAC 591_ PLNLP 596_ LQNNH 601_ TAADM 606_ YLSPV 611_ RSPKK 616_ KGSTT 621_ RVNST 626_ ANAET 631_ QATSA 636_ FQTQK 641_ PLKST 646_ SLSLF 651_ YKKVY 656_ RLAYL 661_ RLNTL 666_ CERLL 671_ SEHPE 676_ LEHII 681_ WTLFQ 686_ HTLQN 691_ EYELM 696_ RDRHL 701_ DQIMM 706_ CSMYG 711_ ICKVK 716_ NIDLK 721_ FKIIV 726_ TAYKD 731_ LPHAV 736_ QETFK 741_ RVLIK 746_ EEEYD 751_ SIIVF 756_ YNSVF 761_ MQRLK 766_ TNILQ 771_ YASTR 776_ PPTLS 781_ PIPHI 786_ PRSPY 791_ KFPSS 796_ PLRIP 801_ GGNIY 806_ ISPLK 811_ SPYKI 816_ SEGLP 821_ TPTKM 826_ TPRSR 831_ ILVSI 836_ GESFG 841_ TSEKF 846_ QKINQ 851_ MVCNS 856_ DRVLK 861_ RSAEG 866_ SNPPK 871_ PLKKL 876_ RFDIE 881_ GSDEA 886_ DGSKH 891_ LPGES 896_ KFQQK 901_ LAEMT 906_ STRTR 911_ MQKQK 916_ MNDSM 921_DTSNK
1: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity)
2: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity