Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]
1_MEEGQ 6_ YSEIE 11_ ELPRR 16_ RCCRR 21_ GTQIV 26_ LLGLV 31_ TAALW 36_ AGLLT 41_ LLLLW 46_ HWDTT 51_ QSLKQ 56_ LEERA 61_ ARNVS 66_ QVSKN 71_ LESHH 76_ GDQMA 81_ QKSQS 86_ TQISQ 91_ ELEEL 96_ RAEQQ 101_ RLKSQ 106_ DLELS 111_ WNLNG 116_ LQADL 121_ SSFKS 126_ QELNE 131_ RNEAS 136_ DLLER 141_ LREEV 146_ TKLRM 151_ ELQVS 156_ SGFVC 161_ NTCPE 166_ KWINF 171_ QRKCY 176_ YFGKG 181_ TKQWV 186_ HARYA 191_ CDDME 196_ GQLVS 201_ IHSPE 206_ EQDFL 211_ TKHAS 216_ HTGSW 221_ IGLRN 226_ LDLKG 231_ EFIWV 236_ DGSHV 241_ DYSNW 246_ APGEP 251_ TSRSQ 256_ GEDCV 261_ MMRGS 266_ GRWND 271_ AFCDR 276_ KLGAW 281_ VCDRL 286_ ATCTP 291_ PASEG 296_ SAESM 301_ GPDSR 306_ PDPDG 311_ RLPTP 316_SAPLH
1: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003)