Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
1_MEDSM 6_ DMDMS 11_ PLRPQ 16_ NYLFG 21_ CELKA 26_ DKDYH 31_ FKVDN 36_ DENEH 41_ QLSLR 46_ TVSLG 51_ AGAKD 56_ ELHIV 61_ EAEAM 66_ NYEGS 71_ PIKVT 76_ LATLK 81_ MSVQP 86_ TVSLG 91_ GFEIT 96_ PPVVL 101_ RLKCG 106_ SGPVH 111_ ISGQH 116_ LVAVE 121_ EDAES 126_ EDEEE 131_ EDVKL 136_ LSISG 141_ KRSAP 146_ GGGSK 151_ VPQKK 156_ VKLAA 161_ DEDDD 166_ DDDEE 171_ DDDED 176_ DDDDD 181_ FDDEE 186_ AEEKA 191_ PVKKS 196_ IRDTP 201_ AKNAQ 206_ KSNQN 211_ GKDSK 216_ PSSTP 221_ RSKGQ 226_ ESFKK 231_ QEKTP 236_ KTPKG 241_ PSSVE 246_ DIKAK 251_ MQASI 256_ EKGGS 261_ LPKVE 266_ AKFIN 271_ YVKNC 276_ FRMTD 281_ QEAIQ 286_DLWQW
1: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)