Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
1_MMEAI 6_ KKKMQ 11_ MLKLD 16_ KENAL 21_ DRAEQ 26_ AEAEQ 31_ KQAEE 36_ RSKQL 41_ EDELA 46_ AMQKK 51_ LKGTE 56_ DELDK 61_ YSEAL 66_ KDAQE 71_ KLELA 76_ EKKAA 81_ DAEAE 86_ VASLN 91_ RRIQL 96_ VEEEL 101_ DRAQE 106_ RLATA 111_ LQKLE 116_ EAEKA 121_ ADESE 126_ RGMKV 131_ IENRA 136_ LKDEE 141_ KMELQ 146_ EIQLK 151_ EAKHI 156_ AEEAD 161_ RKYEE 166_ VARKL 171_ VIIEG 176_ DLERT 181_ EERAE 186_ LAESK 191_ CSELE 196_ EELKN 201_ VTNNL 206_ KSLEA 211_ QAEKY 216_ SQKED 221_ KYEEE 226_ IKILT 231_ DKLKE 236_ AETRA 241_ EFAER 246_ SVAKL 251_ EKTID 256_ DLEDE 261_ LYAQK 266_ LKYKA 271_ ISEEL 276_DHALN
1: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments