Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
1_MAFPP 6_ RRRLR 11_ LGPRG 16_ LPLLL 21_ SGLLL 26_ PLCRA 31_ FNLDV 36_ DSPAE 41_ YSGPE 46_ GSYFG 51_ FAVDF 56_ FVPSA 61_ SSRMF 66_ LLVGA 71_ PKANT 76_ TQPGI 81_ VEGGQ 86_ VLKCD 91_ WSSTR 96_ RCQPI 101_ EFDAT 106_ GNRDY 111_ AKDDP 116_ LEFKS 121_ HQWFG 126_ ASVRS 131_ KQDKI 136_ LACAP 141_ LYHWR 146_ TEMKQ 151_ EREPV 156_ GTCFL 161_ QDGTK 166_ TVEYA 171_ PCRSQ 176_ DIDAD 181_ GQGFC 186_ QGGFS 191_ IDFTK 196_ ADRVL 201_ LGGPG 206_ SFYWQ 211_ GQLIS 216_ DQVAE 221_ IVSKY 226_ DPNVY 231_ SIKYN 236_ NQLAT 241_ RTAQA 246_ IFDDS 251_ YLGYS 256_ VAVGD 261_ FNGDG 266_ IDDFV 271_ SGVPR 276_ AARTL 281_ GMVYI 286_ YDGKN 291_ MSSLY 296_ NFTGE 301_ QMAAY 306_ FGFSV 311_ AATDI 316_ NGDDY 321_ ADVFI 326_ GAPLF 331_ MDRGS 336_ DGKLQ 341_ EVGQV 346_ SVSLQ 351_ RASGD 356_ FQTTK 361_ LNGFE 366_ VFARF 371_ GSAIA 376_ PLGDL 381_ DQDGF 386_ NDIAI 391_ AAPYG 396_ GEDKK 401_ GIVYI 406_ FNGRS 411_ TGLNA 416_ VPSQI 421_ LEGQW 426_ AARSM 431_ PPSFG 436_ YSMKG 441_ ATDID 446_ KNGYP 451_ DLIVG 456_ AFGVD 461_ RAILY 466_ RARPV 471_ ITVNA 476_ GLEVY 481_ PSILN 486_ QDNKT 491_ CSLPG 496_ TALKV 501_ SCFNV 506_ RFCLK 511_ ADGKG 516_ VLPRK 521_ LNFQV 526_ ELLLD 531_ KLKQK 536_ GAIRR 541_ ALFLY 546_ SRSPS 551_ HSKNM 556_ TISRG 561_ GLMQC 566_ EELIA 571_ YLRDE 576_ SEFRD 581_ KLTPI 586_ TIFME 591_ YRLDY 596_ RTAAD 601_ TTGLQ 606_ PILNQ 611_ FTPAN 616_ ISRQA 621_ HILLD 626_ CGEDN 631_ VCKPK 636_ LEVSV 641_ DSDQK 646_ KIYIG 651_ DDNPL 656_ TLIVK 661_ AQNQG 666_ EGAYE 671_ AELIV 676_ SIPLQ 681_ ADFIG 686_ VVRNN 691_ EALAR 696_ LSCAF 701_ KTENQ 706_ TRQVV 711_ CDLGN 716_ PMKAG 721_ TQLLA 726_ GLRFS 731_ VHQQS 736_ EMDTS 741_ VKFDL 746_ QIQSS 751_ NLFDK 756_ VSPVV 761_ SHKVD 766_ LAVLA 771_ AVEIR 776_ GVSSP 781_ DHVFL 786_ PIPNW 791_ EHKEN 796_ PETEE 801_ DVGPV 806_ VQHIY 811_ ELRNN 816_ GPSSF 821_ SKAML 826_ HLQWP 831_ YKYNN 836_ NTLLY 841_ ILHYD 846_ IDGPM 851_ NCTSD 856_ MEINP 861_ LRIKI 866_ SSLQT 871_ TEKND 876_ TVAGQ 881_ GERDH 886_ LITKR 891_ DLALS 896_ EGDIH 901_ TLGCG 906_ VAQCL 911_ KIVCQ 916_ VGRLD 921_ RGKSA 926_ ILYVK 931_ SLLWT 936_ ETFMN 941_ KENQN 946_ HSYSL 951_ KSSAS 956_ FNVIE 961_ FPYKN 966_ LPIED 971_ ITNST 976_ LVTTN 981_ VTWGI 986_ QPAPM 991_ PVPVW 996_ VIILA 1001_ VLAGL 1006_ LLLAV 1011_ LVFVM 1016_ YRMGF 1021_ FKRVR 1026_ PPQEE 1031_ QEREQ 1036_ LQPHE 1041_NGEGN
1: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428)
2: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C
3: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1
4: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8
5: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1
6: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1
7: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus
8: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions