Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)
1_MESKA 6_ LLVLT 11_ LAVWL 16_ QSLTA 21_ SRGGV 26_ AAADQ 31_ RRDFI 36_ DIESK 41_ FALRT 46_ PEDTA 51_ EDTCH 56_ LIPGV 61_ AESVA 66_ TCHFN 71_ HSSKT 76_ FMVIH 81_ GWTVT 86_ GMYES 91_ WVPKL 96_ VAALY 101_ KREPD 106_ SNVIV 111_ VDWLS 116_ RAQEH 121_ YPVSA 126_ GYTKL 131_ VGQDV 136_ ARFIN 141_ WMEEE 146_ FNYPL 151_ DNVHL 156_ LGYSL 161_ GAHAA 166_ GIAGS 171_ LTNKK 176_ VNRIT 181_ GLDPA 186_ GPNFE 191_ YAEAP 196_ SRLSP 201_ DDADF 206_ VDVLH 211_ TFTRG 216_ SPGRS 221_ IGIQK 226_ PVGHV 231_ DIYPN 236_ GGTFQ 241_ PGCNI 246_ GEAIR 251_ VIAER 256_ GLGDV 261_ DQLVK 266_ CSHER 271_ SIHLF 276_ IDSLL 281_ NEENP 286_ SKAYR 291_ CSSKE 296_ AFEKG 301_ LCLSC 306_ RKNRC 311_ NNLGY 316_ EINKV 321_ RAKRS 326_ SKMYL 331_ KTRSQ 336_ MPYKV 341_ FHYQV 346_ KIHFS 351_ GTESE 356_ THTNQ 361_ AFEIS 366_ LYGTV 371_ AESEN 376_ IPFTL 381_ PEVST 386_ NKTYS 391_ FLIYT 396_ EVDIG 401_ ELLML 406_ KLKWK 411_ SDSYF 416_ SWSDW 421_ WSSPG 426_ FAIQK 431_ IRVKA 436_ GETQK 441_ KVIFC 446_ SREKV 451_ SHLQK 456_ GKAPA 461_ VFVKC 466_HDKSL
1: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:11342582, PubMed:27578112, PubMed:8675619). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (PubMed:12032167, PubMed:7592706). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232)