Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)
1_MTSSR 6_ LWFSL 11_ LLAAA 16_ FAGRA 21_ TALWP 26_ WPQNF 31_ QTSDQ 36_ RYVLY 41_ PNNFQ 46_ FQYDV 51_ SSAAQ 56_ PGCSV 61_ LDEAF 66_ QRYRD 71_ LLFGS 76_ GSWPR 81_ PYLTG 86_ KRHTL 91_ EKNVL 96_ VVSVV 101_ TPGCN 106_ QLPTL 111_ ESVEN 116_ YTLTI 121_ NDDQC 126_ LLLSE 131_ TVWGA 136_ LRGLE 141_ TFSQL 146_ VWKSA 151_ EGTFF 156_ INKTE 161_ IEDFP 166_ RFPHR 171_ GLLLD 176_ TSRHY 181_ LPLSS 186_ ILDTL 191_ DVMAY 196_ NKLNV 201_ FHWHL 206_ VDDPS 211_ FPYES 216_ FTFPE 221_ LMRKG 226_ SYNPV 231_ THIYT 236_ AQDVK 241_ EVIEY 246_ ARLRG 251_ IRVLA 256_ EFDTP 261_ GHTLS 266_ WGPGI 271_ PGLLT 276_ PCYSG 281_ SEPSG 286_ TFGPV 291_ NPSLN 296_ NTYEF 301_ MSTFF 306_ LEVSS 311_ VFPDF 316_ YLHLG 321_ GDEVD 326_ FTCWK 331_ SNPEI 336_ QDFMR 341_ KKGFG 346_ EDFKQ 351_ LESFY 356_ IQTLL 361_ DIVSS 366_ YGKGY 371_ VVWQE 376_ VFDNK 381_ VKIQP 386_ DTIIQ 391_ VWRED 396_ IPVNY 401_ MKELE 406_ LVTKA 411_ GFRAL 416_ LSAPW 421_ YLNRI 426_ SYGPD 431_ WKDFY 436_ IVEPL 441_ AFEGT 446_ PEQKA 451_ LVIGG 456_ EACMW 461_ GEYVD 466_ NTNLV 471_ PRLWP 476_ RAGAV 481_ AERLW 486_ SNKLT 491_ SDLTF 496_ AYERL 501_ SHFRC 506_ ELLRR 511_ GVQAQ 516_ PLNVG 521_FCEQE
1: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2 (PubMed:11707436). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901)