Gene name: CALCA

Uniprot entry:

P06881

Protein names:

Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

Protein sequence:

1_MGFQK 6_ FSPFL 11_ ALSIL 16_ VLLQA 21_ GSLHA 26_ APFRS 31_ ALESS 36_ PADPA 41_ TLSED 46_ EARLL 51_ LAALV 56_ QDYVQ 61_ MKASE 66_ LEQEQ 71_ EREGS 76_ RIIAQ 81_ KRACD 86_ TATCV 91_ THRLA 96_ GLLSR 101_ SGGVV 106_ KNNFV 111_ PTNVG 116_ SKAFG 121_RRRRD

Protein annotations

Protein functions:

1: CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)