Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)
1_MWLEI 6_ LLTSV 11_ LGFAI 16_ YWFIS 21_ RDKEE 26_ TLPLE 31_ DGWWG 36_ PGTRS 41_ AARED 46_ DSIRP 51_ FKVET 56_ SDEEI 61_ HDLHQ 66_ RIDKF 71_ RFTPP 76_ LEDSC 81_ FHYGF 86_ NSNYL 91_ KKVIS 96_ YWRNE 101_ FDWKK 106_ QVEIL 111_ NRYPH 116_ FKTKI 121_ EGLDI 126_ HFIHV 131_ KPPQL 136_ PAGHT 141_ PKPLL 146_ MVHGW 151_ PGSFY 156_ EFYKI 161_ IPLLT 166_ DPKNH 171_ GLSDE 176_ HVFEV 181_ ICPSI 186_ PGYGF 191_ SEASS 196_ KKGFN 201_ SVATA 206_ RIFYK 211_ LMLRL 216_ GFQEF 221_ YIQGG 226_ DWGSL 231_ ICTNM 236_ AQLVP 241_ SHVKG 246_ LHLNM 251_ ALVLS 256_ NFSTL 261_ TLLLG 266_ QRFGR 271_ FLGLT 276_ ERDVE 281_ LLYPV 286_ KEKVF 291_ YSLMR 296_ ESGYM 301_ HIQCT 306_ KPDTV 311_ GSALN 316_ DSPVG 321_ LAAYI 326_ LEKFS 331_ TWTNT 336_ EFRYL 341_ EDGGL 346_ ERKFS 351_ LDDLL 356_ TNVML 361_ YWTTG 366_ TIISS 371_ QRFYK 376_ ENLGQ 381_ GWMTQ 386_ KHERM 391_ KVYVP 396_ TGFSA 401_ FPFEL 406_ LHTPE 411_ KWVRF 416_ KYPKL 421_ ISYSY 426_ MVRGG 431_ HFAAF 436_ EEPEL 441_ LAQDI 446_RKFLS
1: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)