Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
1_MPTPD 6_ ATTPQ 11_ AKGFR 16_ RAVSE 21_ LDAKQ 26_ AEAIM 31_ VRGQG 36_ APGPS 41_ LTGSP 46_ WPGTA 51_ APAAS 56_ YTPTP 61_ RSPRF 66_ IGRRQ 71_ SLIED 76_ ARKER 81_ EAAVA 86_ AAAAA 91_ VPSEP 96_ GDPLE 101_ AVAFE 106_ EKEGK 111_ AVLNL 116_ LFSPR 121_ ATKPS 126_ ALSRA 131_ VKVFE 136_ TFEAK 141_ IHHLE 146_ TRPAQ 151_ RPRAG 156_ GPHLE 161_ YFVRL 166_ EVRRG 171_ DLAAL 176_ LSGVR 181_ QVSED 186_ VRSPA 191_ GPKVP 196_ WFPRK 201_ VSELD 206_ KCHHL 211_ VTKFD 216_ PDLDL 221_ DHPGF 226_ SDQVY 231_ RQRRK 236_ LIAEI 241_ AFQYR 246_ HGDPI 251_ PRVEY 256_ TAEEI 261_ ATWKE 266_ VYTTL 271_ KGLYA 276_ THACG 281_ EHLEA 286_ FALLE 291_ RFSGY 296_ REDNI 301_ PQLED 306_ VSRFL 311_ KERTG 316_ FQLRP 321_ VAGLL 326_ SARDF 331_ LASLA 336_ FRVFQ 341_ CTQYI 346_ RHASS 351_ PMHSP 356_ EPDCC 361_ HELLG 366_ HVPML 371_ ADRTF 376_ AQFSQ 381_ DIGLA 386_ SLGAS 391_ DEEIE 396_ KLSTL 401_ YWFTV 406_ EFGLC 411_ KQNGE 416_ VKAYG 421_ AGLLS 426_ SYGEL 431_ LHCLS 436_ EEPEI 441_ RAFDP 446_ EAAAV 451_ QPYQD 456_ QTYQS 461_ VYFVS 466_ ESFSD 471_ AKDKL 476_ RSYAS 481_ RIQRP 486_ FSVKF 491_ DPYTL 496_ AIDVL 501_ DSPQA 506_ VRRSL 511_ EGVQD 516_ ELDTL 521_AHALS
1: Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity)
2: Lacks catalytic activity
3: Lacks catalytic activity