Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase)
1_MCAAR 6_ LAAAA 11_ AAAQS 16_ VYAFS 21_ ARPLA 26_ GGEPV 31_ SLGSL 36_ RGKVL 41_ LIENV 46_ ASLUG 51_ TTVRD 56_ YTQMN 61_ ELQRR 66_ LGPRG 71_ LVVLG 76_ FPCNQ 81_ FGHQE 86_ NAKNE 91_ EILNS 96_ LKYVR 101_ PGGGF 106_ EPNFM 111_ LFEKC 116_ EVNGA 121_ GAHPL 126_ FAFLR 131_ EALPA 136_ PSDDA 141_ TALMT 146_ DPKLI 151_ TWSPV 156_ CRNDV 161_ AWNFE 166_ KFLVG 171_ PDGVP 176_ LRRYS 181_ RRFQT 186_ IDIEP 191_ DIEAL 196_LSQGP
1: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402)