Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
1_MLGVL 6_ VLGAL 11_ ALAGL 16_ GFPAP 21_ AEPQP 26_ GGSQC 31_ VEHDC 36_ FALYP 41_ GPATF 46_ LNASQ 51_ ICDGL 56_ RGHLM 61_ TVRSS 66_ VAADV 71_ ISLLL 76_ NGDGG 81_ VGRRR 86_ LWIGL 91_ QLPPG 96_ CGDPK 101_ RLGPL 106_ RGFQW 111_ VTGDN 116_ NTSYS 121_ RWARL 126_ DLNGA 131_ PLCGP 136_ LCVAV 141_ SAAEA 146_ TVPSE 151_ PIWEE 156_ QQCEV 161_ KADGF 166_ LCEFH 171_ FPATC 176_ RPLAV 181_ EPGAA 186_ AAAVS 191_ ITYGT 196_ PFAAR 201_ GADFQ 206_ ALPVG 211_ SSAAV 216_ APLGL 221_ QLMCT 226_ APPGA 231_ VQGHW 236_ AREAP 241_ GAWDC 246_ SVENG 251_ GCEHA 256_ CNAIP 261_ GAPRC 266_ QCPAG 271_ AALQA 276_ DGRSC 281_ TASAT 286_ QSCND 291_ LCEHF 296_ CVPNP 301_ DQPGS 306_ YSCMC 311_ ETGYR 316_ LAADQ 321_ HRCED 326_ VDDCI 331_ LEPSP 336_ CPQRC 341_ VNTQG 346_ GFECH 351_ CYPNY 356_ DLVDG 361_ ECVEP 366_ VDPCF 371_ RANCE 376_ YQCQP 381_ LNQTS 386_ YLCVC 391_ AEGFA 396_ PIPHE 401_ PHRCQ 406_ MFCNQ 411_ TACPA 416_ DCDPN 421_ TQASC 426_ ECPEG 431_ YILDD 436_ GFICT 441_ DIDEC 446_ ENGGF 451_ CSGVC 456_ HNLPG 461_ TFECI 466_ CGPDS 471_ ALARH 476_ IGTDC 481_ DSGKV 486_ DGGDS 491_ GSGEP 496_ PPSPT 501_ PGSTL 506_ TPPAV 511_ GLVHS 516_ GLLIG 521_ ISIAS 526_ LCLVV 531_ ALLAL 536_ LCHLR 541_ KKQGA 546_ ARAKM 551_ EYKCA 556_ APSKE 561_ VVLQH 566_VRTER
1: Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed:10761923). Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway (PubMed:29323190, PubMed:33836597, PubMed:9395524). Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition (PubMed:26663133). Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (By similarity). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response (PubMed:15841214)