Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
1_MAKDF 6_ QDIQQ 11_ LSSEE 16_ NDHPF 21_ HQGEG 26_ PGTRR 31_ LNPRR 36_ GNPFL 41_ KGPPP 46_ AQPLA 51_ QRLCS 56_ MVCFS 61_ LLALS 66_ FNILL 71_ LVVIC 76_ VTGSQ 81_ SEGHG 86_ GAQLQ 91_ AELRS 96_ LKEAF 101_ SNFSS 106_ STLTE 111_ VQAIS 116_ THGGS 121_ VGDKI 126_ TSLGA 131_ KLEKQ 136_ QQDLK 141_ ADHDA 146_ LLFHL 151_ KHFPV 156_ DLRFV 161_ ACQME 166_ LLHSN 171_ GSQRT 176_ CCPVN 181_ WVEHQ 186_ GSCYW 191_ FSHSG 196_ KAWAE 201_ AEKYC 206_ QLENA 211_ HLVVI 216_ NSWEE 221_ QKFIV 226_ QHTNP 231_ FNTWI 236_ GLTDS 241_ DGSWK 246_ WVDGT 251_ DYRHN 256_ YKNWA 261_ VTQPD 266_ NWHGH 271_ ELGGS 276_ EDCVE 281_ VQPDG 286_ RWNDD 291_ FCLQV 296_ YRWVC 301_ EKRRN 306_ATGEV
1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface