Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
1_MGFSS 6_ ELCSP 11_ QGHGV 16_ LQQMQ 21_ EAELR 26_ LLEGM 31_ RKWMA 36_ QRVKS 41_ DREYA 46_ GLLHH 51_ MSLQD 56_ SGGQS 61_ RAISP 66_ DSPIS 71_ QSWAE 76_ ITSQT 81_ EGLSR 86_ LLRQH 91_ AEDLN 96_ SGPLS 101_ KLSLL 106_ IRERQ 111_ QLRKT 116_ YSEQW 121_ QQLQQ 126_ ELTKT 131_ HSQDI 136_ EKLKS 141_ QYRAL 146_ ARDSA 151_ QAKRK 156_ YQEAS 161_ KDKDR 166_ DKAKD 171_ KYVRS 176_ LWKLF 181_ AHHNR 186_ YVLGV 191_ RAAQL 196_ HHQHH 201_ HQLLL 206_ PGLLR 211_ SLQDL 216_ HEEMA 221_ CILKE 226_ ILQEY 231_ LEISS 236_ LVQDE 241_ VVAIH 246_ REMAA 251_ AAARI 256_ QPEAE 261_ YQGFL 266_ RQYGS 271_ APDVP 276_ PCVTF 281_ DESLL 286_ EEGEP 291_ LEPGE 296_ LQLNE 301_ LTVES 306_ VQHTL 311_ TSVTD 316_ ELAVA 321_ TEMVF 326_ RRQEM 331_ VTQLQ 336_ QELRN 341_ EEENT 346_ HPRER 351_ VQLLG 356_ KRQVL 361_ QEALQ 366_ GLQVA 371_ LCSQA 376_ KLQAQ 381_ QELLQ 386_ TKLEH 391_ LGPGE 396_ PPPVL 401_ LLQDD 406_ RHSTS 411_ SSEQE 416_ REGGR 421_ TPTLE 426_ ILKSH 431_ ISGIF 436_ RPKFS 441_ LPPPL 446_ QLIPE 451_ VQKPL 456_ HEQLW 461_ YHGAI 466_ PRAEV 471_ AELLV 476_ HSGDF 481_ LVRES 486_ QGKQE 491_ YVLSV 496_ LWDGL 501_ PRHFI 506_ IQSLD 511_ NLYRL 516_ EGEGF 521_ PSIPL 526_ LIDHL 531_ LSTQQ 536_ PLTKK 541_ SGVVL 546_ HRAVP 551_ KDKWV 556_ LNHED 561_ LVLGE 566_ QIGRG 571_ NFGEV 576_ FSGRL 581_ RADNT 586_ LVAVK 591_ SCRET 596_ LPPDL 601_ KAKFL 606_ QEARI 611_ LKQYS 616_ HPNIV 621_ RLIGV 626_ CTQKQ 631_ PIYIV 636_ MELVQ 641_ GGDFL 646_ TFLRT 651_ EGARL 656_ RVKTL 661_ LQMVG 666_ DAAAG 671_ MEYLE 676_ SKCCI 681_ HRDLA 686_ ARNCL 691_ VTEKN 696_ VLKIS 701_ DFGMS 706_ REEAD 711_ GVYAA 716_ SGGLR 721_ QVPVK 726_ WTAPE 731_ ALNYG 736_ RYSSE 741_ SDVWS 746_ FGILL 751_ WETFS 756_ LGASP 761_ YPNLS 766_ NQQTR 771_ EFVEK 776_ GGRLP 781_ CPELC 786_ PDAVF 791_ RLMEQ 796_ CWAYE 801_ PGQRP 806_ SFSTI 811_ YQELQ 816_SIRKR
1: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28