Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]
1_MQPSS 6_ LLPLA 11_ LCLLA 16_ APASA 21_ LVRIP 26_ LHKFT 31_ SIRRT 36_ MSEVG 41_ GSVED 46_ LIAKG 51_ PVSKY 56_ SQAVP 61_ AVTEG 66_ PIPEV 71_ LKNYM 76_ DAQYY 81_ GEIGI 86_ GTPPQ 91_ CFTVV 96_ FDTGS 101_ SNLWV 106_ PSIHC 111_ KLLDI 116_ ACWIH 121_ HKYNS 126_ DKSST 131_ YVKNG 136_ TSFDI 141_ HYGSG 146_ SLSGY 151_ LSQDT 156_ VSVPC 161_ QSASS 166_ ASALG 171_ GVKVE 176_ RQVFG 181_ EATKQ 186_ PGITF 191_ IAAKF 196_ DGILG 201_ MAYPR 206_ ISVNN 211_ VLPVF 216_ DNLMQ 221_ QKLVD 226_ QNIFS 231_ FYLSR 236_ DPDAQ 241_ PGGEL 246_ MLGGT 251_ DSKYY 256_ KGSLS 261_ YLNVT 266_ RKAYW 271_ QVHLD 276_ QVEVA 281_ SGLTL 286_ CKEGC 291_ EAIVD 296_ TGTSL 301_ MVGPV 306_ DEVRE 311_ LQKAI 316_ GAVPL 321_ IQGEY 326_ MIPCE 331_ KVSTL 336_ PAITL 341_ KLGGK 346_ GYKLS 351_ PEDYT 356_ LKVSQ 361_ AGKTL 366_ CLSGF 371_ MGMDI 376_ PPPSG 381_ PLWIL 386_ GDVFI 391_ GRYYT 396_ VFDRD 401_ NNRVG 406_FAEAA
1: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease