Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
1_MSTVH 6_ EILCK 11_ LSLEG 16_ DHSTP 21_ PSAYG 26_ SVKAY 31_ TNFDA 36_ ERDAL 41_ NIETA 46_ IKTKG 51_ VDEVT 56_ IVNIL 61_ TNRSN 66_ AQRQD 71_ IAFAY 76_ QRRTK 81_ KELAS 86_ ALKSA 91_ LSGHL 96_ ETVIL 101_ GLLKT 106_ PAQYD 111_ ASELK 116_ ASMKG 121_ LGTDE 126_ DSLIE 131_ IICSR 136_ TNQEL 141_ QEINR 146_ VYKEM 151_ YKTDL 156_ EKDII 161_ SDTSG 166_ DFRKL 171_ MVALA 176_ KGRRA 181_ EDGSV 186_ IDYEL 191_ IDQDA 196_ RDLYD 201_ AGVKR 206_ KGTDV 211_ PKWIS 216_ IMTER 221_ SVPHL 226_ QKVFD 231_ RYKSY 236_ SPYDM 241_ LESIR 246_ KEVKG 251_ DLENA 256_ FLNLV 261_ QCIQN 266_ KPLYF 271_ ADRLY 276_ DSMKG 281_ KGTRD 286_ KVLIR 291_ IMVSR 296_ SEVDM 301_ LKIRS 306_ EFKRK 311_ YGKSL 316_ YYYIQ 321_ QDTKG 326_ DYQKA 331_LLYLC
1: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)
2: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen