Complement component C8 beta chain (Complement component 8 subunit beta)
1_MKNSR 6_ TWAWR 11_ APVEL 16_ FLLCA 21_ ALGCL 26_ SLPGS 31_ RGERP 36_ HSFGS 41_ NAVNK 46_ SFAKS 51_ RQMRS 56_ VDVTL 61_ MPIDC 66_ ELSSW 71_ SSWTT 76_ CDPCQ 81_ KKRYR 86_ YAYLL 91_ QPSQF 96_ HGEPC 101_ NFSDK 106_ EVEDC 111_ VTNRP 116_ CRSQV 121_ RCEGF 126_ VCAQT 131_ GRCVN 136_ RRLLC 141_ NGDND 146_ CGDQS 151_ DEANC 156_ RRIYK 161_ KCQHE 166_ MDQYW 171_ GIGSL 176_ ASGIN 181_ LFTNS 186_ FEGPV 191_ LDHRY 196_ YAGGC 201_ SPHYI 206_ LNTRF 211_ RKPYN 216_ VESYT 221_ PQTQG 226_ KYEFI 231_ LKEYE 236_ SYSDF 241_ ERNVT 246_ EKMAS 251_ KSGFS 256_ FGFKI 261_ PGIFE 266_ LGISS 271_ QSDRG 276_ KHYIR 281_ RTKRF 286_ SHTKS 291_ VFLHA 296_ RSDLE 301_ VAHYK 306_ LKPRS 311_ LMLHY 316_ EFLQR 321_ VKRLP 326_ LEYSY 331_ GEYRD 336_ LFRDF 341_ GTHYI 346_ TEAVL 351_ GGIYE 356_ YTLVM 361_ NKEAM 366_ ERGDY 371_ TLNNV 376_ HACAK 381_ NDFKI 386_ GGAIE 391_ EVYVS 396_ LGVSV 401_ GKCRG 406_ ILNEI 411_ KDRNK 416_ RDTMV 421_ EDLVV 426_ LVRGG 431_ ASEHI 436_ TTLAY 441_ QELPT 446_ ADLMQ 451_ EWGDA 456_ VQYNP 461_ AIIKV 466_ KVEPL 471_ YELVT 476_ ATDFA 481_ YSSTV 486_ RQNMK 491_ QALEE 496_ FQKEV 501_ SSCHC 506_ APCQG 511_ NGVPV 516_ LKGSR 521_ CDCIC 526_ PVGSQ 531_ GLACE 536_ VSYRK 541_ NTPID 546_ GKWNC 551_ WSNWS 556_ SCSGR 561_ RKTRQ 566_ RQCNN 571_ PPPQN 576_ GGSPC 581_ SGPAS 586_ETLDC
1: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:7440581). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328, PubMed:7440581). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328, PubMed:7440581). C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself (PubMed:30552328). During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity (PubMed:30552328, PubMed:6833260)